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Tensartan (Losartan)
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Tensartan

Tensartan and associated names, 12,5 mg, 25mg, 50 mg, 100 mg, film-coated tablets is an orally active angiotensin II (Ang- II) receptor antagonist, Tensartan, acting on the AT1 receptor subtype, thus blocking the effect of Ang-II in the renin angiotensin system (RAS) cascade. Tensartan is indicated for the treatment of hypertension.

Other names for this medication:
Angibloc, Asart, Cardon, Cardoplus, Cardzaar, Czartan, Hypozar, Insaar, Lavestra, Lorista, Losapres, Losartil, Losatrix, Lozap, Lozatan, Ocsaar, Prelow, Ranlozar, Rasoltan, Resilo, Sanipresin, Sarvas, Sarvastan, Sarve, Stadazar, Tensiohess, Xartan

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Also known as: Losartan

Description

Tensartan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Tensartan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Tensartan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Tensartan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Tensartan 25 mg, Tensartan 50 mg, and Tensartan 100 mg may also contain carnauba wax.

Dosage

Take Tensartan tablets orally with or without food. Do not crush or chew it. Take Tensartan once or twice a day at the same time. If you want to achieve most effective results do not stop taking Tensartan suddenly.

Overdose

If you overdose Tensartan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Tensartan overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Tensartan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Tensartan as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Tensartan. Correct volume or salt depletion prior to administration of Tensartan.

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The amino acid substitutions do not prevent envelope precursor cleavage, viral core and genome assembly, or receptor binding. Biologically active compounds based on the privileged 2-imidazoline scaffold: The world beyond adrenergic/imidazoline receptor modulators. We planned to include all randomised controlled trials focusing on HIV prevention advice versus standard care or comparing HIV prevention advice with other more focused methods of delivering care or information for people with serious mental illness. Hence sexual selection may enhance populational extinction by increasing selection load under environmental changes. Characteristics of two cases with dup(15)(q11.2-q12): one of maternal and one of paternal origin. The dominant question of the origin of plant phytochromes is difficult to tackle because the patterns differ among phylogenetic trees. Angular displacement of the trunk was measured using a motion analyzer. The utility of the valve was demonstrated by a one-step, fully automatic implementation of a complex pesticide assay requiring timed, sequential exposure of an immobilized enzyme layer to separate liquid streams. Well-controlled translational study in clinically applicable and reproducible models is needed to guide evidence-based clinical management of this important phenomenon.

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Here, we investigated the effect of 2 important factors (e.g., cell concentration and stirring) on ethanol production from sugarcane bagasse hydrolysate using the yeast Scheffersomyces stipitis immobilized in calcium alginate matrix. This study supports the efficacy of patient education in improving proficiency in eye drop instillation and in reducing pain and irritation following cataract extraction surgeries. Such a correction effect of DHD on HH correlates with that on the detoxification enzyme eGST and on pGSH. A decade of structural variants: description, history and methods to detect structural variation. Here we review these findings, integrate them into current models of hippocampal-dependent learning and suggest how improvement in our understanding of neurobiological oscillations is critical for theories of medial temporal lobe processes underlying intact and pathological learning.

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The field of antiangiogenesis is expanding rapidly, with an increasing number of agents currently approved by the FDA. aureus, lipoteichoic acid (LTA) and lipopolysaccharides (LPS) and investigate the effect of the ligands mannan and LTA and anti-DC-SIGN antibodies 1C6 and 4H3 on the binging of sDC-SIGN to S. A large parosteal osteosarcoma with transformation to high-grade osteosarcoma: a case report. Cardiovascular pathophysiology: is it a tumour necrosis factor superfamily affair?. Improving uptake and use of malaria rapid diagnostic tests in the context of artemisinin drug resistance containment in eastern Myanmar: an evaluation of incentive schemes among informal private healthcare providers. The results obtained can be useful for designing of new active mimetics of BDNE.

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Ultraviolet (UV) light has become widely accepted for the disinfection of potable water, process water and wastewater as an alternative to chlorination. CIMT, but neither FRS nor ORS, is independently associated with stroke among Nigerian African hypertensive patients. Castor oil is considered the only commercially renewable source of hydroxylated fatty acids, which have many applications as chemical reactants. Carbohydrate metabolism was studied in fourteen patients with myotonia dystrophica (MD) using oral glucose, fructose and galactose tolerance tests. Intracellular recordings in hippocampal slices showed that glutamine did not alter either excitatory or inhibitory synaptic activity, suggesting that the observed memory impairments may not result from conversion of glutamine to either glutamate or GABA. The administration of 1 g of the ethylsuccinate immediately after a meal gave a peak serum concentration after 60 min of 3.36 micrograms/ml. adults aged 50 and older, on health and economic outcomes of CRC screening. We found that strain GR4, which is less prone to translocate on solid surfaces than strain Rm1021, is more efficient in developing biofilms on glass and plant root surfaces.

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