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Tanlozid (Losartan)
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Tanlozid

Tanlozid belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Tanlozid prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Tanlozid slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Anreb, Biortan, Cardon, Cartan, Corodin, Cosart, Covance, Cozaarex, Eklips, Enromic, Fensartan, Klosartan, Lakea, Lavestra, Loben, Logika, Lohyp, Loortan, Lortaan, Losacar, Losagen, Losan, Losapot, Losapres, Losardil, Losartanum, Losartec, Losartil, Losavik, Lospre, Lostan, Lostat, Loxibin, Lozatan, Maxartan, Medzar, Niten, Normatens, Osartan, Ozarium, Portiron, Ranlozar, Rasoltan, Resilo, Sarilen, Sarlo, Sarve, Simperten, Tensaar, Tensiohess

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Also known as: Losartan

Description

Tanlozid (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Tanlozid is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Tanlozid is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Tanlozid 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Tanlozid 25 mg, Tanlozid 50 mg, and Tanlozid 100 mg may also contain carnauba wax.

Dosage

Take Tanlozid tablets orally with or without food. Do not crush or chew it. Take Tanlozid once or twice a day at the same time. If you want to achieve most effective results do not stop taking Tanlozid suddenly.

Overdose

If you overdose Tanlozid and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Tanlozid overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Tanlozid are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Changes in renal function including acute renal failure can be caused by drugs that inhibit the reninangiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on COZAAR. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Tanlozid.

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Tetrade analysis has established the two complementation groups as unlinked. In heritable PAH, the most common mutation is in the BMPR2 gene, which regulates growth, differentiation and apoptosis of mesenchymal cells. There are a number of effective and cost-effective e-health applications available for treating depression in community and clinical settings. Normal development of tyrosine hydroxylase and serotonin immunoreactive fibers innervating anterior cingulate cortex and visual cortex in rabbits exposed prenatally to cocaine. We also demonstrate that tumor cells are unable to generate NAD by de novo synthesis as they lack expression of key enzymes in this pathway, thus providing a mechanistic rationale for the reliance of tumor cells on the NAD salvage pathway. The influence of environmental carcinogens on the developing embryo has been investigated using SWA mice as models and 1-ethyl-1-nitrosourea (ENU) as the carcinogen. New insights into the stem cells and the precursors of the gastric epithelium. Despite a slower evolution, intestinal transplantation is currently the standard therapy for patients with intestinal failure and life-threatening parenteral nutrition complications. Parent, peer, and executive function relationships to early adolescent e-cigarette use: a substance use pathway?.

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Potential antifertility agents from plants: a comprehensive review. Polypathology, malnutrition, polytherapy, length of stay in the hospital and residence in nursing-home contribute to the increasing incidence and gravity of these diseases with aging. Connecting the microtubule attachment status of each kinetochore to cell cycle arrest through the spindle assembly checkpoint. A retrospective analysis of 19 patients with esophagogastric or intestinal varices secondary to extrahepatic portal hypertension was conducted. Amino acid decarboxylation by whole cells of the original hosts was determined as well. E-cadherin expression in human breast cancer cells suppresses the development of osteolytic bone metastases in an experimental metastasis model. Inflammatory markers and the pathogenesis of pediatric depression and suicide: a systematic review of the literature.

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Endobronchial laser therapy induces proliferative and metabolic processes in the tunica propria of the mucous membrane. Repetitive transcranial magnetic stimulation (rTMS) has attracted attention as a putative clinical neuromodulatory tool, including for ameliorating hallucinations, although existing clinical data are inconsistent. In this study, IIR was significantly correlated with postoperative survival. Graded requirement for the spliceosome in cell cycle progression. T2DM positively affected creatine and myoinositol peak areas from the left hippocampus, rather than metabolites in the left frontal lobe. The mechanism of allotype suppression in rabbits has been investigated by studying the in vitro immune responses of spleen cells from rabbits in advanced stages of spontaneous recovery from suppression. First, a face to face counsel and mental intervention for more than 30 minutes was given to smoker, then 4 interventions through telephone call for 15-20 minutes for each time were conducted 1 week later, 1 month later, 3 months later and 6 months later, respectively. Descriptive statistics on the frequency distribution of the demographic characteristics, knowledge, and use of mouthguards as well as the relationships between the type of mouthguard worn and questions related to mouthguard use.

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Neonatal mouse hip joint and hindlimb anomalies induced by prenatal exposure to Ara-C. Our cases demonstrate that NTM disease is sometimes accompanied by OP adalat histologically, and some such cases show common clinical features. Its risk factors have been ranked to intraoperative risk factors. Interpretation of survival-curve data for Chinese hamster cells, line V-79 using the multi-target, multi-target with initial slope, and alpha, beta equations. Spectroscopic study and optical and electrical properties of Ti-doped ZnO thin films by spray pyrolysis. Evidence on screening for breast cancer from a randomized trial. The objective of this retrospective cohort study was to investigate the driving habits of glaucoma patients and to determine the conformance of their visual acuity and visual fields with driving regulations. This metabolic condition allows investigations intended to activate metabolic processes and to restore the steady state of metabolic parameters.

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miR-203 enhances chemosensitivity to 5-fluorouracil by targeting thymidylate synthase in colorectal cancer. This is the first in a series of articles exploring principles and topics relevant to teams guiding clinicians involved in cancer care. This study tests the hypothesis that a brief intervention to facilitate the use of telephone quitline services for both initial and follow-up counseling is effective in helping patients achieve sustained abstinence. Lung tissue expression and plasma concentration of ET-1 increased during INO, and plasma ET-1 increased further after its withdrawal. The feasibility and requirements of multiple gated data acquisition in positron ECT were investigated for 13NH3, (18F)-2-fluoro-2-D-deoxyglucose, and (11C)-carboxyhemoglobin.

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