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Sigmaxin (Digoxin)

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Sigmaxin induces an increase in intracellular sodium that will drive an influx of calcium in the heart and cause an increase in contractility. Cardiac output increases with a subsequent decrease in ventricular filling pressures. Sigmaxin has vagomimetic effects on the AV node.

Other names for this medication:
Agoxin, Cardiacin, Cardiogoxin, Digacin, Digibind, Digitek, Digobal, Digohan, Digoregen, Digosin, Digossina, Digoxen, Digoxin, Digoxine, Digoxinum, Eudigox, Fargoxin, Halfdigoxin, Lanadicor, Lanibos, Lanicor, Lenoxin, Purgoxin, Sigmaxin, Vidaxil

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Moduretic, Bystolic, Cordarone, Zebeta, Coreg, Benicar, Lopressor, Norvasc, Avapro, Diovan

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Also known as: Digoxin


Sigmaxin target is struggle against certain types of fast heartbeats such as atrial fibrillation or fluttering arrhythmia and heart failure. It is also treats angina. This drug can also be used after heart attack. The effectiveness of Sigmaxin is in keeping the heart rhythm under control and to make heart work better (regularly and strongly). It is cardiac (or digitalis) glycosides. Generic name of Sigmaxin is Digoxin. Sigmaxin is also known as Digoxin, Digitalis, Digitek, Lanoxicaps. Brand names of Sigmaxin are Lanoxicaps, Sigmaxin, Cardoxin, Digitek, Sigmaxin Elixir Pediatric.


Take Sigmaxin tablets (0.25 mg), capsules and pediatric elixir (liquid) orally. Elderly people (> 65 years) should take the lowest dose. Take Sigmaxin at the same time once a day with water. Do not crush or chew it. If you want to achieve most effective results do not stop taking Sigmaxin suddenly.


If you overdose Sigmaxin and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Sigmaxin overdosage: confusion, irregular heartbeats, nausea, seizures, vomiting, extremely fast or slow heartbeats, hallucinations, tiredness, problems with vision, diarrhea, lack of appetite.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Sigmaxin are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Sigmaxin if you are allergic to Sigmaxin components. Do not take Sigmaxin if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Sigmaxin if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Be careful with Sigmaxin in case of taking medicines as a steroid medicine (prednisone (such as Deltasone), methylprednisolone (such as Medrol), prednisolone (such as Prelone, Pediapred), dexamethasone (such as Decadron)); a cancer chemotherapy drug; amphotericin B (such as Fungizone); indomethacin (such as Indocin); rifampin (such as Rifadin, Rimactane); cholestyramine (such as Questran, Prevalite) or colestipol (such as Colestid); a thyroid medication; a beta-blocker (atenolol (such as Tenormin), propranolol (such as Inderal), acebutolol (such as Sectral), metoprolol (such as Lopressor), carteolol (such as Cartrol), labetalol (such as Normodyne, Trandate) or nadolol (such as Corgard)); a diuretic (hydrochlorothiazide (such as HCTZ, HydroDiuril, others), chlorothiazide (such as Diuril), chlorthalidone (such as Hygroton, Thalitone), furosemide (such as Lasix), torsemide (such as Demadex), bumetanide (such as Bumex), ethacrynic acid (such as Edecrin), triamterene (such as Dyrenium, Maxzide, Dyazide), amiloride (such as Midamor), spironolactone (such as Aldactone), eplerenone (such as Inspra)); metoclopramide (such as Reglan); tetracycline (such as Broadspec, Emtet, Panmycin, Sumycin, Tetracap); erythromycin (such as E.E.S., E-Mycin, Eryc, Ery-Tab, PCE) or clarithromycin (such as Biaxin); sulfasalazine (such as Azulfidine); sulfasalazine (such as Azulfidine); another medicines for irregular heartbeats (quinidine (such as Quinidex, Quinora, Cardioquin), amiodarone (such as Cordarone) or propafenone (such as Rythmol)); itraconazole (such as Sporanox); a calcium channel blocker (diltiazem (such as Cardizem, Dilacor XR, Tiazac), amlodipine (such as Norvasc), felodipine (such as Plendil), nifedipine (such as Procardia, Adalat), verapamil (such as Verelan, Calan, Isoptin, Covera-HS)), an antacid or laxative that contains aluminum, magnesium or kaolin-pectin (such as Maalox, Rolaids, Mylanta, Milk of Magnesia). Be careful with Sigmaxin if you have allergies to medicines, foods, or other substances. Be careful with Sigmaxin if you suffer from or have a history of thyroid disease, cancer, kidney disease, heart arrhythmias. Use Sigmaxin with great care in case you want to undergo an operation (dental or any other). Elderly people (> 65 years) should take the lowest dose. Avoid alcohol. Avoid machine driving. Do not stop taking Sigmaxin suddenly.

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This study was performed using the EYESi ophthalmic surgical simulator. In the Xinjiang Uyghur Autonomous Region in China, chronic sun-induced damage MM is the most prevalent MM among Chinese Uyghur patients, whereas acral and mucosal MMs are the most prevalent in Uyghur patients. Definitions of continuity during training and the role continuity measurement plays in residency need further study. Decrease in size of intrathoracic meningocele following insertion of a ventriculo-venous shunt. A receiver-operating characteristic (ROC) curve was used to evaluate the predictive value of AMSA for ROSC. How well do radiographic, clinical and self-reported diagnoses of knee osteoarthritis agree?. The three de novo assembled transcriptomes provide a comprehensive sequence resource for molecular genetic research in grape. A hydrodynamic active polar gel theory is used to model the cytoplasm of a cell and is combined with a Helfrich-type model to account for membrane properties. Self-assembled nanoscale architecture of TiO2 and application for dye-sensitized solar cells. Kinetic Curve Type Assessment for Classification of Breast Lesions Using Dynamic Contrast-Enhanced MR Imaging.

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While adhesion and costimulatory molecules in the immunological synapse impact upon the overall force of the interaction, these results suggest that the TCR uses a force-dependent bond - a catch bond - and that it may therefore be important to consider the TCR-pMHC interaction in isolation in the early phases of the decision process. Medical records of adolescents aged 12-21years, diagnosed with arterial or venous TE (AT/DVT) from 2004 to 2014, were retrospectively reviewed and analyzed with IRB approval. To assess the impact of prenatal exposure to Maillard reaction products (MRPs) -rich diet and postnatal Coca-Cola consumption on metabolic status of female rats. The rH index for quality and environmental controls: standards and application procedures. Alignment of structural and DTI data and derivation of diffusion index maps were performed using Analysis of Functional NeuroImages software followed by Tract-Based Spatial Statistics using FMRIB Software Library. A genetic polymorphism in RBP4 is associated with coronary artery disease.

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Using a mycobacteria identification algorithm, which includes the molecular method PRA, improves the diagnostic power of conventional methods and could help to advance both NTM epidemiology knowledge and mycobacteriosis control. This systematic review included searches for both peer reviewed and gray literature. circulans and the plasmid ColE1-ApR were digested with EcoRI endonuclease and the resulting fragments covalently joined with polynucleotide ligase. Maintenance therapy is continued during the benign chronic phase of the disease. The patient responded well to therapy with appropriate cytotoxic and antimicrobial agents. Using administrative health data we identified persons with MS and an age-, sex- and geographically-matched general population (GP) cohort. A total of 4,790 proteins have been identified using shotgun proteomics approach with 2D LC, which to our knowledge is the most comprehensive study for zebrafish liver tumor proteome. In both patients, surgery was needed to restore normal renal function and to prevent further renal damage. The first is that all samples were allocated to families with three or more first-degree relatives affected (FNMTC-3 group) and families with only two affected first-degree relatives (FNMTC-2 group).

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Median follow-up time after FDG-PET was 33.1 months (range, 5-83 months) for all patients and 22.4 months (range, 5-83 months) for patients with positive PET results. New ultrastructural findings of Klebsiella rhinoscleromatic bacilli were described. Early intervention in female drug users, routine involvement of first-line healthcare providers and increased attention to use of poly- and psychotropic prescription drugs might contribute to prevent premature drug-related death and reduce gender differences. Twenty New-Zealand white rabbits were used in the present study. Risk of antenatal psychosocial distress in indigenous women and its management at primary health care centres in Australia.

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Cancer of the oesophagus and gastroesophageal junction - a difficult clinical problem. We examined VM in two human breast cancer cell lines with different aggressive capabilities (MDA-MB-231 and MCF-7 cells) and one human umbilical vein endothelial cell line (HUVEC). Importantly, during competitive assays with albitiazolium, the binding of choline/ethanolamine phosphotransferase (the enzyme involved in the last step of phosphatidylcholine synthesis) was substantially displaced, thus confirming the efficiency of this strategy for searching albitiazolium targets. Phase 1 was an analysis of NR domain evolution and the results were used to guide the design of phase 2, a codon-model-based survey for alterations of natural selection within the hominids. Our findings support the assumption that clustering of receptors and conformational changes in membrane structure are prerequisites for mitogenic stimulation.

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The TREAT-NMD advisory committee for therapeutics (TACT): an innovative de-risking model to foster orphan drug development. Preimmunization of the appropriate nonresponder strain with GAT or GT inhibits both the secondary IgM and IgG responses to GAT-MBSA and GT-MBSA, respectively. To our knowledge, this is the first example of cleavable signal peptides for proteins transported into the outer membrane of cyanobacteria. Examining the Preferred Self-Controlled KR Schedules of Learners and Peers During Motor Skill Learning. We report the first Japanese case of spinal muscular atrophy phenotype associated with lamin A/C mutation.

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This case demonstrates the advantage of magnetic resonance imaging and transesophageal echocardiography for tumor detection over transthoracic echocardiography and computed tomography and the usefulness of transesophageal echocardiography for guiding the right atrial endomyocardial biopsy procedure. THE INFLUENCE OF VITREOMACULAR ADHESION ON OUTCOMES AFTER AFLIBERCEPT THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION. Approximately 1/4 of PEx are associated with failure to recover lung function and/or resolve symptoms. Overall survival correlations of c-MET and phospho-c-MET immunostainings were investigated in 157 malignant pleural mesothelioma patients for whom paraffin-embedded specimens were referred to our center for pathological diagnosis certification (MESOPATH French National group). An increase in puerperal hemorrhage after more than 3 hours of second stage labor was attributable to those patients delivered by midforceps operations. It is, therefore, less clear if LUTS are risk factors for falls in men. The primary outcome measure was creatinine clearance within the first two days after surgery. We benchmark and validate the methodology using simulations of hen egg white lysozyme in solution, a well-studied system for which extensive experimental data, including osmotic second virial coefficients, small-angle scattering structure factors, and multiple structures determined by X-ray and neutron crystallography and solution NMR, as well as rigid-body BD simulation results, are available for comparison. The O(3)-enhanced airway responses were present in tracheal segments cultured for 24 h, a procedure shown to deplete sensory nerves while maintaining viability of intrinsic airway neurons, and all the enhanced smooth muscle responses were also diminished by CP-99994. Voice Handicap Index 10 (VHI-10) was used for subjective analysis.

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This case illustrates that lung transplantation could be a therapeutic option in selected patients with BO after allogeneic BMT that is associated with extensive chronic GVHD and who are refractory to conventional immunosuppressive therapy. Blood glucose, however, was elevated in diabetic patients taking phenytoin, and the incidence of undesirable side effects was increased. Anticoagulation seems to have been effective and should be considered even in patients without visible thrombus on echocardiography. They often experience secondary education disadvantage with inadequate subject choices, pathways and opportunities. A single cyclin-CDK complex is sufficient for both mitotic and meiotic progression in fission yeast. Laser-induced interstitial thermotherapy is an experimental technique used to destroy tumors within the liver. They also showed more variability of BVP following the longer intertriai interval, but showed less variability following the introduction of the high tone. Here we provide a background to this project, discussing the history of the comet assay and practical issues that can critically affect its performance. These spleen cell donors had no detectable anticryptococcal antibody. The age, activity before surgery, activity after surgery, anesthesia, medical illness, and the time between fracture and surgery were significantly associated with the mortality as single factor.

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Functional characterization of a sialyltransferase-deficient mutant of Neisseria gonorrhoeae. Agenesis of the ductus venosus and its correlation to hydrops fetalis and the fetal hepatic circulation: case reports and review of the literature. The intensities of the spectral bands assigned to the vibrations of the phosphate and the fatty acid chain increased to a maximum as the applied potential was increased. For an n-fluid-phase system, n(n-1)/2 contact angles can be defined, but there are (n-1)(n-2)/2 constraints between them, leaving only n-1 independent values of the contact angle. The Importance of Awareness and Education in Patients with Breast Cancer-Related Lymphedema. The value of long-term follow-up of patients after retinal detachment surgery depends on the number of further detachments prevented. Zygosaccharomyces kombuchaensis CBS8849 and Kazachstania gamospora CBS10400 demonstrated positive organoleptic properties and suitable fermentation dynamics, rapid sugar consumption and industrial strain compatibility. Severe internal hemorrhages due to spontaneous intestinal rupture in hemodialysis patients.

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This review discusses the rationale for combining the antibiotics as well as some emerging or existing combinations. Due to the different terminal carbohydrate residues, glycoproteins of adult, fetal or transformed cells can be separated using affinity chromatography. Molecular characterization of BZR transcription factor family and abiotic stress induced expression profiling in Brassica rapa. In contrast, GMD differences were found in the UC group in the left anterior lobe and dentate nucleus of the cerebellum. ATRA inhibited the UVA irradiation-induced decrease in prolidase activity through an insulin-like growth factor (IGF) receptor signaling pathway in HDEs. It deserves more clinical studies to assess its efficacy as no randomized controlled trials have been performed with flavoxate during the last decade. This review describes the clinical and immunological features of APECED and discusses emerging alternative models norvasc generic name to explain the pathogenesis of the disease. We conducted a retrospective review of medical records at the Family Practice Center from 1992 to 1993. The aims of this study were to examine the inter-item correlations and factor structure of the COWS in opioid-dependent men and women.

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A brief overview of antimicrobial peptides containing unnatural amino acids and ligand-based approaches for peptide ligands. They also contain idiosyncratic usage and are unlikely to contain the linguistic constructs associated with synonym and hierarchy identification. An electronic survey consisting of nine closed multiple-choice questions was circulated to all 435 registered BAOS members. The impact of transcatheter aortic valve implantation on quality of life: results from the German transcatheter aortic valve interventions registry. However, the strength of promoter activity in vitro does not correlate well with Ly49 expression in vivo and forward promoter activity is generally weak or undetectable, suggesting that components outside of Pro1 are required for efficient forward transcription. Clinicians were more pessimistic about the well-being of their lung cancer patients compared with patients with other solid tumors.

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Swept source optical coherence tomography imaging can identify PVF and cisterns occurring in the context of age-related VD, and PVF appeared to be possible precursors of cisterns. A comparison between clinical and roentgenological examination of patients. Bioactive peptides (BAPs), derived through enzymatic hydrolysis of food proteins, have demonstrated potential for application as health-promoting agents against numerous human health and disease conditions, including cardiovascular disease, inflammation, and cancer. Evaluation of body adiposity index as a predictor of aortic stiffness in multi-ethnic Asian population with type 2 diabetes. Diagnostic genotyping of ABCA4 is complicated by the large size of the gene and the existence of approximately 600 known pathogenic variations, along with numerous rare polymorphisms. Because these lesions have a grave prognosis, the need for timely diagnostic evaluation and aggressive surgical management is emphasized. Results showed evidence of an bystolic cost savings unconscious CSPCE in reaction times (RTs) and the N2 and P3 components. Milk formulae for term-born infants supplemented with docosahexaenoic acid (DHA) resulted in DHA concentration in the red cells comparable to values observed in breast-fed infants without influence on visual acuity. Utilizing graphene as an active load with tunable conductivity, we can significantly modify the local-field enhancement and strongly modulate the THz wave transmission. The number of items with full agreement between observers increased with the use of SIG.

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These results, together with recently published data demonstrating lower circulating CNDP1 in subjects with glioblastoma and metastatic prostate cancer, suggest that CNDP1 may constitute a marker of aggressive cancer and CC. In contrast, worker bees have only few ovarioles and are essentially sterile. Single-incision versus conventional laparoscopic distal pancreatectomy: a single-institution case-control study. After initially spreading in North America, the virus spread globally resulting in the first influenza pandemic since 1968. The results showed that the vascular sounds at the anastomosis can be characterized as an extra energy in the higher frequencies (200-1000 Hz) i.e. Flexion MRI permits better visualization of HILs on T2-weighted sequences. Spirometry and blood gas analysis revealed complete recovery of pulmonary function. This review article is meant to guide physicians through the optimal use of chemotherapy in CRPC patients in daily clinical practice.

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Our aim was to assess whether an lasix 20 mg im hcpcs elevated VEint suggests the presence of COPD in HF. This important estimation capability is addressed for small groups and single-subject designs in pilot studies for clinical trials, medical and therapeutic clinical practice. Subsequently, he was diagnosed with severe bilateral vesicoureteral reflux (right side grade V, left side grade III), and was administered trimethoprim/sulfamethoxazole as the prophylaxis. Improving physical activity is an accepted main line of strategy for overcoming poor body composition, hypertension and reduced cardio respiratory fitness (CRF) all of which are considered as independent risk factors for the development of future cardiovascular complications. Further, overexpression of FASN is sufficient to stimulate cell proliferation. Transitive inference deficits in unaffected biological relatives of schizophrenia patients.

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These methods are simple and sensitive for the early detection of subtle changes in the left atrial function. After multiple chemotherapies, many patients still have a good performance status and are eligible for radioembolization. In order to study the prognosis of RIS, multicentre studies, or case-control studies are recommended. The difference in mean alveolar pressure between a normal and a diseased alveolus depends on the difference in time constant between those alveoli, regardless of the mode of ventilation. However, in active packaging, several variables must be considered, such as temperature control and different gas formulations with different product types and microorganisms. Rotavirus-induced diarrhea is responsible for the death of approximately 800,000 children per year. This review will therefore provide an overview of the current concepts regarding remyelination in the rodent and human CNS. This includes for example most spline-based models, but also statistical shape or deformation models. This paper presents a comparative study over the respiratory pattern classification task involving three missing data imputation techniques, and four different machine learning algorithms. Collectively, glaucophyte, red, and green microalgae contain the machineries involved in repressive histone H3 lysine methylation, DNA cytosine methylation, and RNA interference.

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To increase transplant rates in sensitized patients, new protocols for HLA and blood type incompatible (ABOi) desensitization have emerged. In patients with AF, apixaban more often prevented stroke or systemic embolism and death and caused less bleeding than zebeta medication side effect warfarin, regardless of the presence of prior CAD. Inheritance of extra triradii of palmar interdigital areas II and IV. Phenomenological research methodology was used to explore the preferences of 10 SLPs. The purpose of this study was to construct a scoring system for predicting the probability of LE after ALND for Chinese breast cancer patients.

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Pseudomonas aeruginosa is an opportunistic bacterial pathogen that causes fatal acute lung infections in critically ill individuals. Studies of T lymphocyte function and inhibitory factors in minimal change nephrotic syndrome. Patients with thyroid metastases appear to live much longer with a more indolent course. A monopole microwave catheter with a sideways firing axially symmetrical heating pattern was designed. Military service members (SMs) and veterans who sustain mild traumatic brain injuries (mTBI) during combat deployments often have co-morbid conditions but are reluctant to seek out therapy in medical or mental health settings. The parent study was performed in the PECARN (Pediatric Emergency Care Applied Research Network). The ELISA system was applied with four antigens to detect antibodies against E6 and E7 proteins of human papillomavirus types 16 and 18. amiloride class of drug Thirty-nine rearranged chromosomes containing a portion of Chr17 were observed.

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A bisoprolol review of the literature and a report of a case of necrotizing sialometaplasia of the hard palate is presented. The most common congenital disorder of glycosylation (CDG), phosphomannomutase 2 (PMM2)-CDG, is caused by mutations in PMM2 that limit availability of mannose precursors required for protein N-glycosylation. To report a clonal outbreak of ST17 vancomycin-resistant Enterococcus faecium (VREfm) carrying Tn1546 (vanA) in a haemo-oncology ward of a tertiary teaching hospital in the south of Spain (January-September 2009). Human infestation to ectoparasites such as ticks, lice, cimex, fleas, mites and others agents may result in intensive allergic reaction with symptoms of itching, skin infection and severe irritation. Influence of the 5-HT(2C) receptor antagonist SB242,084 on behaviour produced by the 5-HT(2) agonist Ro60-0175 and the indirect 5-HT agonist dexfenfluramine. This case report stresses the importance of attaining proper disinfection of the root canal system for a predictable long-term outcome of the treatment. Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia. The aim of this study was to evaluate the prognostic value of MSI-H and p53 overexpression in metastatic colorectal cancer (mCRC) treated with oxaliplatin and fluoropyrimidine-based first line chemotherapy. Survivors of severe AKI in the POST-RENAL study had lower physical and mental components of HRQOL compared with general population, even after adjustment for their reduced renal function. HIV-1 envelope glycoprotein (Env) spikes are prime vaccine candidates, at least in principle, but suffer from instability, molecular heterogeneity and a low copy number on virions.

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Harm reduction strategies commonly include needle and syringe programmes (NSP), opioid substitution therapy (OST) and interventions combining these two strategies. However, Cu(II) ions decrease water-oxidizing activity of layered Mn oxides. The WRKY genes have been identified as important transcriptional modulators predominantly during the environmental stresses, but they also play critical role at various stages of plant life cycle. In the vitreous of the untreated control eyes only minimal or no ampicillin was found in all of our experiments. It is concluded that furnishings and textiles in the classroom act as significant reservoirs of irritants and allergens and have an impact on the indoor air quality at school.

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This dual facilitation was obtained when the cues were shown only at test or during both study and test and regardless of whether or not the subjects were explicitly aware of the additional sensory contingency. We report a case of pediatric onychopapilloma that presented with monodactylous longitudinal erythronychia. We hypothesized that the magnitude of the paired associative stimulation (PAS)-induced long-term potentiation (LTP)-like effect depends on the number of pairs in the PAS protocol. Protective autoimmunity: regulation and prospects for vaccination after brain and spinal cord injuries. EDS is an uncommon, heterogeneous disease of abnormal collagen production with potentially fatal sequelae. In this Grand Round, we present the case of an otherwise healthy adolescent female patient, who, despite aggressive management, succumbed to C gattii meningoencephalitis.

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