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Repace (Losartan)
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Repace

Repace and associated names, 12,5 mg, 25mg, 50 mg, 100 mg, film-coated tablets is an orally active angiotensin II (Ang- II) receptor antagonist, Repace, acting on the AT1 receptor subtype, thus blocking the effect of Ang-II in the renin angiotensin system (RAS) cascade. Repace is indicated for the treatment of hypertension.

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Also known as: Losartan

Description

Repace (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Repace is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Repace is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Repace 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Repace 25 mg, Repace 50 mg, and Repace 100 mg may also contain carnauba wax.

Dosage

Take Repace tablets orally with or without food. Do not crush or chew it. Take Repace once or twice a day at the same time. If you want to achieve most effective results do not stop taking Repace suddenly.

Overdose

If you overdose Repace and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Repace overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Repace are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Changes in renal function including acute renal failure can be caused by drugs that inhibit the reninangiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on COZAAR. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Repace.

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To clarify the relationship between colonization of periodontopathic bacteria and cytokines, we evaluated profiles of inflammatory cytokines, chemokine, anti-inflammatory cytokines, and inducible nitric oxide synthase (iNOS) and colonization by Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans, which are major pathogens of periodontitis. Intrahepatic cholangiocarcinoma (ICC) is a highly aggressive tumor of the bile duct, and a significant public health problem in East Asia, where it is associated with infection by the parasite Opisthorchis viverrini. There is no evidence that any one regimen is associated with fewer side-effects. The status of large vessels in overweight and obesity according to ultrasound findings. Precise localization of human beta-globin gene complex on chromosome 11. Indeed, AMDE-1 triggered necroptosis and was preferentially cytotoxic to cancer cells. Three-dimensional feather like bayerite/boehmite nanocomposites were synthesized by a facile one-pot hydrothermal method. According to literature data this histological type of the gastrointestinal lymphoma has poor response to chemotherapy, the prognosis is unfavourable. We here used two different RNA-seq datasets, de novo transcriptome assemblies, homology-based comparisons, and trained ab initio gene callers to generate a new gene annotation of Z.

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Distinction was made between lesion type, location, and procedural sedation and analgesic (PSA). Evaluation of a multiplex real time reverse transcription PCR assay for the detection and quantitation of the most common human rotavirus genotypes. Patient demographics, Lund-Mackay computed tomography (CT) scores, 22-item Sino-Nasal Outcome Test (SNOT-22) scores, disease characteristics, and medication use were collected prior to FESS. Breast reduction is a common procedure used to improve physical and aesthetic factors associated with breast hypertrophy. Factors affecting synonymous codon usage bias in chloroplast genome of oncidium gower ramsey. Recently evolving health care systems including prescriptions should use these findings obtained from the study. Variability, heritability and association of some morpho-agronomic traits in field pea (Pisum sativum L.) genotypes. We excluded PUNLMP diagnosed after a previous or with a concurrent urothelial neoplasm. This reduced working memory capacity led to a pronounced increase in reaction time and errors when mental addition was performed concurrently with a memory load task.

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Space-regaining therapy is an important treatment modality in the management of developing occlusions. The three sectors recorded similar levels of pro-rich distribution in 2003, but in 2007, the private-not-for-profit sector was pro-poor, public sector benefits showed an equal distribution, while the private-for-profit sector remained pro-rich. Constitutive and inducible NOS isoforms convert L-arginine to NO and L-citrulline. CAP sleep in insomnia: new methodological aspects for sleep microstructure analysis. All three polymers display a multilayer build-up in linear profiles as demonstrated by UV spectroscopy. Given these findings, understanding the biochemical signaling events controlling apoptosis is a first step towards developing therapeutic agents which would target this cell death process.

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Its ability to be easily propagated and its high phenotypic variability make it an ideal model system for functional, ecological and evolutionary genetics. Confidential illness reports were completed by all individuals with symptoms of AGI, and samples of fecal matter and vomitus, surface swabs of rafting equipment, and environmental swabs at stops along the hiking corridor were collected and tested for the presence of norovirus using reverse transcription-quantitative polymerase chain reaction (RT-qPCR). jejuni isolates were grouped by random amplification of polymorphic DNA (RAPD) profiling. This norvasc pill image finding, while reassuring, does not exclude the possibility of more subtle deficits. Recent experiments have showed that state-of-the-art descriptors provide better performances on the far-infrared (FIR) spectrum than on the visible one, even in daytime conditions, for pedestrian classification. The transformed base plan was used as the computed plan for each femur. The simulation results clearly show that the proposed CSB-II method is robust to sensing noise. Percutaneous sacroiliac screw for unstable type C 1-2 hip bone fracture: about a case at the University Hospital of Yaounde.

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We aimed to give voice to how healthcare workers in two East African hospitals identify and explain the major obstacles to ensuring the safety of patients in their care. To determine the correlation among the clinical characteristics of pruritus, psoriasis scalp severity index (PSSI), and intraepidermal nerve fiber (IENF) density in psoriatic scalp lesions. The proliferating mesenchymal cells surrounding the epithelia of the efferent ductules have arranged in several concentric layers at about 85 days. The reconstruction of extensive femoral defects, particularly septic, by revascularized free fibula flap has become part of routine practice for many years. Thus, while decreased bioavailability probably plays a role in the protection seen after i.p. FMD viral RNA isolation, cDNA synthesis, and polymerase chain reaction were performed calan 120 mg to synthesize expression cassettes (P1-2AB3BC(wt) and P1-2AB3BC(m)) followed by cloning in pShuttle-CMV vector.

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