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Lotim (Losartan)
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Lotim

Lotim slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes. to treat patients with high blood pressure (hypertension) in adults and in children and adolescents 6 - 18 years of age.

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Also known as: Losartan

Description

Lotim (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Lotim is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Lotim is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Lotim 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Lotim 25 mg, Lotim 50 mg, and Lotim 100 mg may also contain carnauba wax.

Dosage

Take Lotim tablets orally with or without food. Do not crush or chew it. Take Lotim once or twice a day at the same time. If you want to achieve most effective results do not stop taking Lotim suddenly.

Overdose

If you overdose Lotim and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Lotim overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Lotim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Lotim as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Lotim. Correct volume or salt depletion prior to administration of Lotim.

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Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy. Graft and patient survival are better in late than early liver retransplant and in predictive index category III than IV. Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. Benign bladder tumors of mesenchymal origin have a very low appearance incidence, being the most frequent the leiomyoma. Although its specificity and sensitivity are reportedly high, there remains some disagreement over this point. The potential for recovery is low, but injection augmentation can relieve symptoms. A large proportion of healthy older individuals show memory decline, which may represent the early stages of a potentially more severe cognitive impairment. Our objective was to evaluate outcomes of a strategy using mucosal grafts to decrease postoperative closure. One hertz rTMS led to attenuation of the underlying auditory cortex response to the stimulus and a contralateral increase in cortical activity.

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Age-Independent Cartilage Generation for Synovium-Based Autologous Chondrocyte Implantation. B cells and lymphocytes with Fc receptors were only a few in synovial fluid. Worldwide, breast cancer is the second most prevalent cancer among women and its incidence is increasing alarmingly. Environmental effects played a paramount role in shaping the expression of the fitness-related traits measured in this wild population, but two of them, condition and haematocrit, retained significant heritable variation. We hypothesized that ezrin, one of the ERM family members, may play important roles in ECs organization during angiogenesis, and new vessels formation in preexisting tissues. Elevated plasma concentrations of pigment epithelium-derived factor in type 2 diabetic patients is reduced by metformin treatment in association with weight loss 2. While early disease detection is critical to prevent chronic lung remodeling and complications later in life, BPD is often difficult to diagnose and prevent due to the lack of good biomarkers for identification of infants at risk, and overlapping symptoms with other diseases, such as pulmonary hypertension (PH). Genomic heritabilities and genomic estimated breeding values for methane traits in Angus cattle. Above threshold, the energy distributions of both analyte and matrix cations are constant over a broad range of amiloride 5 mg oral laser intensities. The radiation dose of neutron is closely related to the neutron energy, and the connected relationship is a complex function of energy.

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