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Lotim (Losartan)

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Lotim slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes. to treat patients with high blood pressure (hypertension) in adults and in children and adolescents 6 - 18 years of age.

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Also known as: Losartan


Lotim (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Lotim is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Lotim is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Lotim 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Lotim 25 mg, Lotim 50 mg, and Lotim 100 mg may also contain carnauba wax.


Take Lotim tablets orally with or without food. Do not crush or chew it. Take Lotim once or twice a day at the same time. If you want to achieve most effective results do not stop taking Lotim suddenly.


If you overdose Lotim and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Lotim overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Lotim are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Lotim as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Lotim. Correct volume or salt depletion prior to administration of Lotim.

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Asymmetric catalytic ene-cyclization approach to 2-fluoro-19-nor-1,25-dihydroxyvitamin D(3) A-ring analog with significant transactivation activity. The vitamin D, ionised calcium and parathyroid hormone axis of cerebral capillary function: therapeutic considerations for vascular-based neurodegenerative disorders. Thus, in this review, we chose to gather significant and typical examples of intelligent materials, which comprise MSNs surface-immobilized with molecular and supramolecular switches, and overview their wide applications in many fields such as controlled release of cargo molecules for disease therapy and cell imaging. We selected and divided them into two groups depending on whether they corresponded to the first or second graft. Related cortical representations have been proposed to shape emotional experience and guide behavior. Thus, at a daily exposure to 10 ppm the exhaled benzene concentration in the morning after a day of exposure will not exceed 0.1 ppm. We will use mixed-effect models to evaluate the primary and secondary outcomes, where pretest score functions as a covariate, treatment condition is a between-subjects factor, and the multivariate outcome reflects scores for a given assessment at the three time points. We presented the relationship between the dose variation and each parameters using regression analysis, and we could derive the approximation formula for estimating the dose variation using these parameters.

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Multiple gestations in assisted reproductive technology: can they be avoided with blastocyst transfers?. Vitreoretinal diseases, macular degeneration, diabetic retinopathy are no longer considered problematic. Types of lasers used in treatment of retinal diseases include argon, diode, dye and multicolor lasers, micropulse lasers and lasers for photodynamic therapy. The enhanced expression of Gb3 in primary breast carcinomas and its lymph node metastases indicate that the development of STxB-based therapeutic strategies is of interest in this pathology. This paper introduces an alternative approach to the conventional confidence prediction that addresses some of this and other disadvantages. We found no significant differences between the predictive validity of the trial-studying test and prior educational performance, and substantial shared explained variance between the two predictors. To determine whether computer-predicted short RNA structural analogues could inhibit hepatitis C virus (HCV) genotype 2a, 3a and 4a replication in cultured cells. Peripheral blood lymphocytes did not respond to CGRP, suggesting that receptors are present only on a subpopulation of thymocytes but not on mature T cells. Effects of sleep deprivation on serum cortisol level and mental health in servicemen. Emergency computed tomography revealed extensive retroperitoneal hematoma and inferior vena cava angiography revealed extravasation.

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Reduced IGF signaling prevents muscle cell death in a Caenorhabditis elegans model of muscular dystrophy. Graft and patient survival are better in late than early liver retransplant and in predictive index category III than IV. Mutation of Asp(171) and Asp(262) of the chemokine receptor CXCR4 impairs its coreceptor function for human immunodeficiency virus-1 entry and abrogates the antagonistic activity of AMD3100. Benign bladder tumors of mesenchymal origin have a very low appearance incidence, being the most frequent the leiomyoma. Although its specificity and sensitivity are reportedly high, there remains some disagreement over this point. The potential for recovery is low, but injection augmentation can relieve symptoms. A large proportion of healthy older individuals show memory decline, which may represent the early stages of a potentially more severe cognitive impairment. Our objective was to evaluate outcomes of a strategy using mucosal grafts to decrease postoperative closure. One hertz rTMS led to attenuation of the underlying auditory cortex response to the stimulus and a contralateral increase in cortical activity.

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Macrocystic tumors (six cases) were unilocular and limited by a thick wall containing nests of tumor cells. Induced magnetization, induced relative rotation and the director are mutually orthogonal, with the director aligned obliquely to the flow direction. Here, we established cardiac hypertrophy models for feeding spontaneously hypertensive rats (SHRs) aged 10, 20, and 30 weeks. Evidence-based persuasive message design can be informed by dependable research-based generalizations about the relative persuasiveness of alternative message-design options. However, subdural-peritoneal shunting plus cranioplasty thoroughly resolves the subdural hygroma collection, which might deteriorate the cerebrospinal fluid circulation, leading to hydrocephalus. Recurrent somatic alterations in myeloid malignancies of key proteins involved in DNA methylation, post-translational histone modification and chromatin remodeling have highlighted the importance of epigenetic regulation of gene expression in the initiation and maintenance of various malignancies.

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Age-Independent Cartilage Generation for Synovium-Based Autologous Chondrocyte Implantation. B cells and lymphocytes with Fc receptors were only a few in synovial fluid. Worldwide, breast cancer is the second most prevalent cancer among women and its incidence is increasing alarmingly. Environmental effects played a paramount role in shaping the expression of the fitness-related traits measured in this wild population, but two of them, condition and haematocrit, retained significant heritable variation. We hypothesized that ezrin, one of the ERM family members, may play important roles in ECs organization during angiogenesis, and new vessels formation in preexisting tissues. Elevated plasma concentrations of pigment epithelium-derived factor in type 2 diabetic patients is reduced by metformin treatment in association with weight loss 2. While early disease detection is critical to prevent chronic lung remodeling and complications later in life, BPD is often difficult to diagnose and prevent due to the lack of good biomarkers for identification of infants at risk, and overlapping symptoms with other diseases, such as pulmonary hypertension (PH). Genomic heritabilities and genomic estimated breeding values for methane traits in Angus cattle. Above threshold, the energy distributions of both analyte and matrix cations are constant over a broad range of amiloride 5 mg oral laser intensities. The radiation dose of neutron is closely related to the neutron energy, and the connected relationship is a complex function of energy.

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