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Lotan (Losartan)

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Lotan belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Lotan is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

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Also known as: Losartan


Lotan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Lotan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Lotan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Lotan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Lotan 25 mg, Lotan 50 mg, and Lotan 100 mg may also contain carnauba wax.


Take Lotan tablets orally with or without food. Do not crush or chew it. Take Lotan once or twice a day at the same time. If you want to achieve most effective results do not stop taking Lotan suddenly.


If you overdose Lotan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Lotan overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Lotan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Lotan as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Lotan. Correct volume or salt depletion prior to administration of Lotan.

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Preterm Birth Reduces Nutrient Absorption With Limited Effect on Immune Gene Expression and Gut Colonization in Pigs. Acupuncture as a Treatment Option in Treating Posttraumatic Stress Disorder-Related Tinnitus in War Veterans: A Case Presentation. In these cases conservation programmes should be initiated in order to maintain or even increase their number. HCV RNA was not only found in hepatocyte plasma but also in cholangiolar epithelia and monocytes. The essence of the collective neurodynamic optimization approach lies in its potential to solve constrained global optimization problems in real time.

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Hormone replacement therapy (HRT) is becoming more common when managing brain-dead donors. Variable neural adaptive robust control strategies are proposed for the output tracking control of a class of multiinput multioutput uncertain systems. This indicates that probiotics may be more beneficial than placebo for preventing acute URTIs. The diagnosis of neurosyphilis was made in 10 out of 14 cases with progressive neurological disease and reactive serum rapid plasma reagin, luorescent treponemal absorbent-absorbent antibodies and treponemal pallidum hemagglutination. Incidence of end-stage renal disease due to hypertension has increased in recent decades, but the optimal strategy for treatment of hypertension to prevent renal failure is unknown, especially among African Americans. VIP (VP-16, ifosfamide, cisplatin) regimen was employed as salvage regimen in cases where other combinations failed. Despite the low incidence of the cochleotoxic and and vestibulotoxic side-effects of tobramycin, it seems advisable to monitor patients on tobramycin therapy for signs of vestibular dysfunction and hearing loss. Magnesium protects against anaphylactic shock and cardiac myolysis in guinea-pigs. Thirty cases of CTS were treated with electroacupuncture at Quchi (LI 11), Yangchi (TE 4), Shousanli (LI 10), Neiguan (PC 6) and Hegu (LI diovan 160mg tablet 4) on the affected side, combined with semiconductor laser irradiation at Shenmen (HT 7) and Yangxi (LI 5) on the affected side. The defective urethra was repaired by using the Thiersch-Duplay principle at the second stage.

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Integrated backscatter intravascular ultrasound (IB-IVUS) plaque tissue characterization may detect vulnerable plaque with high local plaque inflammation. Aging is associated with a loss of muscle mass (sarcopenia) and function. The use of external fixation devices in orthopedic surgery is very common in open tibial fractures. Performance of self-collected cervical samples in screening for future precancer using human papillomavirus DNA testing. Up to date have demonstrated that more and more young people are affected by chronic liver diseased. To evaluate the effects of a constant rate infusion of remifentanil, alone or in combination with ketamine, in healthy cats anesthetized with isoflurane. Surgical management of snapping scapula is a safe and viable treatment option for patients who fail nonoperative treatment. Group II mGluRs modulate baseline and arthritis pain-related synaptic transmission in the rat medial prefrontal cortex. MPMRI and BOLD hypoxia imaging provide information regarding tumor biology at the molecular, subcellular, cellular and tissue levels and this information may be used as an appropriate and reliable biologic target for radiation dose painting to optimize adalat blood pressure medication therapy in future.

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We also examined the incorporation of red quantum dots (QDs) to improve the color rendering index of the WLEDs with the aid of nano-silica amiloride cost as a rheological additive. Synthesis and biological evaluation of pseudolaric acid B derivatives as potential immunosuppressive agents. Further research is needed to determine how forgiving OCs are of various pill-taking errors, to determine the impact of dual method use (eg, OCs and condoms), and to assess the effects of user, method, and programmatic characteristics on correct and consistent use and, in turn, on effectiveness. Waxy near-isogenic lines with a non-functional Wx-D1d allele showed consistently increased NL, GL and PL contents among FL and MGDG, DGDG and PC contents among NSL compared with non-waxy near-isogenic lines with a functional Wx-D1a allele throughout three growing/harvest seasons. It has been clear for some time that the development of telecare faces significant problems.

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Epigenetic mechanisms establish/maintain alterations in gene expression in the brain, providing the impetus for investigations characterizing how epigenetic processes mediate the effects of drugs of abuse. D-dimer: An Overview of Hemostasis and Fibrinolysis, Assays, and Clinical Applications. Vancomycin-resistant enterococci have emerged as major nosocomial pathogens worldwide. These data provide a rationale for investigation of the role of CHKA in further models of de novo and acquired resistance to AIs, and provide proof of concept that integrative genomic analyses can identify biologically relevant modulators of AI response. Methods used include a gel mobility shift competition assay using purified AGM alpha-satellite, a novel kinetic electrophoretic mobility shift assay competition protocol using bulk genomic DNA, and bulk sequencing of 76 AGM alpha-satellite monomers. Consumer exposure modelling under REACH: Assessing the defaults. Of these, 13 patients from 11 unrelated families had ten novel and one reported SMCHD1 mutations: four splice-site, two nonsense, two in-frame deletion, two out-of-frame deletion, and one missense mutations.

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These findings suggest that mutual upregulation of ET-1 and IL-25 takes place in the epidermis of AD, which may be a future target for antipruritic agents. Does patient perception of shoulder balance correlate with clinical balance?. The slot angulations that are built into currently manufactured brackets are the same as those recommended more than 20 years ago. The data recorded were combined with millimeter-wave data for FeF in the X(6)Delta state and fitted with an effective Hamiltonian to determine the major parameters for FeF in the X(6)Delta, (6)Pi, and (6)Phi electronic levels. Recent work on the DNA-binding properties of transcription activator-like effector (TALE) proteins has shown that their specificity also relies on only a few key residues with a predictable code that can be used to design new DNA-binding proteins. These include mutations in the genes for LPL, APOC2, GPIHBP1, LMF1 and APOA5. All these processes must be under intricate and coordinated control, as they have to be integrated across all tissues. Systemic metastatic retinal lymphoma (SMRL) originates in systemic organs. It is argued that by using this type of approach, the real value of intelligent CBL to provide individual formative advice to students in a simulated experience can be realized. Functional assays revealed MIR125B1 is a bona fide target gene of Nrf2.

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Social isolation stress increased the nitrite levels in comparison with those in SC mice, whereas 7-NI and L-NAME, unlike aminoguanidine, mitigated the effect of SIS. The SOC mass fraction also had similar depth distribution pattern in this soil layer. An articulation of these differences can be of interest to health care managers and to psychotherapy researchers. Multiple myeloma associated with extramedullary plasmacytoma causing nerve root compression: a case report. These results demonstrate a robust capacity to perform the SMFA in a medium-to-high throughput format, suitable for assessing large numbers of experimental samples of candidate antibodies or drugs. We propose a cross-correlation method to map the transverse velocities of particles moving in capillary vessels using full-field time-varying laser speckle technique. Study sample was mainly composed of adults with type 1 diabetes and study was not blinded. Ideally, clinicians should discuss the rationale for steroid use, and the risks, expected benefits, and alternatives of the steroid therapy.

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This study assessed the possible effect of hydrochlorothiazide (HCT) on soothing recurrent abdominal pain (RAP). Computerized hemodynamic evaluation of the cerebral circulation for bypass. Children with multiple disabilities (G1) and healthy children (G2) were compared in time, frequency, and non-linear domains. Analysis of acylcarnitine levels by tandem mass spectrometry in epileptic children receiving valproate and oxcarbazepine. Practicality of the procedure was assessed, and cats were monitored for immediate and delayed effects. This 2-year retrospective study used timelapse technology to investigate the PCOS-influence on timing of development in the pre-implantation embryo (primary endpoint). Possible health effects of occupational exposure continue to be the subject of extensive research. The established lines all carried the Thy-1.1 antigenic marker of T lymphocytes. Lumbosacral dumb-bell neurilemmoma approached by microsurgical interlaminar foraminotomy. In the present study, we investigated the mechanisms of BDNF-induced cell migration in colon cancer cells.

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