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Losium (Losartan)

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Losium slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes. to treat patients with high blood pressure (hypertension) in adults and in children and adolescents 6 - 18 years of age.

Other names for this medication:
Angibloc, Anreb, Biortan, Cardzaar, Cartan, Covance, Fortzaar, Forzaar, Hypozar, Lorista, Losap, Losapres, Losartan, Lotim, Niten, Ozarium, Rasertan, Rasoltan, Resilo, Rosatan, Sanipresin, Sartaxal, Sarvas, Sarve, Zaart, Zartan

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Also known as: Losartan


Losium (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Losium is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Losium is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Losium 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Losium 25 mg, Losium 50 mg, and Losium 100 mg may also contain carnauba wax.


Take Losium tablets orally with or without food. Do not crush or chew it. Take Losium once or twice a day at the same time. If you want to achieve most effective results do not stop taking Losium suddenly.


If you overdose Losium and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Losium overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Losium are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Losium if you are allergic to Losium components. Do not take Losium if you're pregnant or you plan to have a baby, or you are a nursing mother. Losium can harm your baby. Do not use Losium if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Losium if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Losium suddenly.

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Finding the global minimum: a fuzzy end elimination implementation. After a single oral dose of sildenafil (1 mg/kg), method evidenced poor metabolism in these patients. Two percent of 826 adults examined during routine dental check-up visits show torsiversion in their molars. Qualitative skeletal correlates of wing shape in extant birds (Aves: Neoaves). These stresses may have negative effects on the mental health and performance of the nurses and physicians. To evaluate the cost-effectiveness of nodal staging surgery before chemoradiotherapy (CRT) for locally advanced cervical cancer in the era of positron emission tomography/computed tomography (PET/CT). Nanoparticles (NPs), in particular noble metal nanoparticles, have been incorporated into many therapeutic and biodiagnostic applications.

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Antibacterial Activity of DNA-Stabilized Silver Nanoclusters Tuned by Oligonucleotide Sequence. Postpartum pelvic floor muscle training and urinary incontinence: a randomized controlled trial. Electron microscopy showed this protein to be situated within the dilated lumina of the endoplasmic reticulum of the hepatocytes. A total of 673 mothers who had given birth during a one-year-period were interviewed using a structured questionnaire. These findings, and the noninvasiveness of CT, make this technique one of the most accurate means of radiological investigation of DI and also of determining the efficacy of therapy. Thus, developmental studies of these mutants designed to describe or dissect the biochemical basis of the induction of the mutant phenotype are now feasible. The twin pregnancies presented obstetric complications but these were not unusual. We sought to determine whether or not evidence supporting this recommendation exists by reviewing available literature.

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To study the dynamics of the reinfection of Schistosoma japonicum and related risk factors among the people in schistosomiasis endemic areas in China. The cancer stem cell (CSC) concept derives from the fact that cancers are dysregulated tissue clones whose continued propagation is vested in a biologically distinct subset of cells that are typically rare. The development of a safe and effective vaccine for prevention of AIDS has thus far proven to be exceedingly difficult due to the complexities associated with HIV pathogenesis including but not limited to antigenic hypervariability, multiple routes and modes of transmission, a lack of defined correlates of protective immunity, and a tropism for infection of immunoregulatory cells which are essential for orchestrating an effective host immune response. The performance of PCI-based risk scores is not well-described among patients undergoing hemodynamically supported high risk PCI. Toward a unified biological hypothesis for the BDNF Val66Met-associated memory deficits in humans: a model of impaired dendritic mRNA trafficking. HEV generally causes a self-limited acute infection and treatment remains supportive. Two cognitive interview techniques were applied: Thinking Aloud (TA) during the assessment and Verbal Probing (VP) afterwards. The preclinical characterization of novel phenyl(piperazin-1-yl)methanones that are histamine H3 receptor antagonists is described. We evaluated the morphology of stent graft and aorta remodeling and the volumetric changes in these patients after successful TEVAR. On each of 5 consecutive days, two groups received either a central infusion of saline or an infusion of the corticotropin-releasing factor antagonist, astressin.

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Diagnosis depends on NMDAR antibody testing, which may not be readily available. The study reports 10-year anatomical and visual outcome in patients who underwent pars plana vitrectomy (PPV) for complications due to proliferative diabetic retinopathy (PDR). Lexical use in emotional autobiographical narratives of persons with schizophrenia and healthy controls. Transcriptome Response Mediated by Cold Stress in Lotus japonicus. Morris water maze was employed to investigate its effects on learning and memory and then clarify its possible mechanisms relating the central cholinergic system and BDNF. This was further supported by the in silico binding affinity of UA-4 and UA-5 with efflux pump proteins. In a retrospective analysis, data were obtained for all women with ICP admitted to two centers in Guangzhou, China, between February 1, 1993, and January 31, 2014.

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Oncolytic viruses are a novel anticancer therapy with the ability to target tumor cells, while leaving healthy cells intact. Affinity to tumor antigen failed to augment tumor uptake of Fab above non-specific accumulation, which suggests that Fab fragments of typical monoclonal antibodies may fall below an affinity threshold for use as molecular imaging agents. The present study represents the first attempt to characterize chromosomes in An. Our study showed a lower prevalence of atrial fibrillation, ischemic heart disease and hypercholesterolemia in Chinese, and mostly similar risk factor associations in Chinese and Caucasian ischemic stroke patients. Standard enrichment methods for targeted next-generation sequencing in high-repeat genomic regions. Five medical centers in the United States and the United Kingdom. Synthetic small molecules that induce neuronal differentiation in neuroblastoma and fibroblast cells. DPCPX can induce P53 expression which consequently promotes the cell apoptosis in MCF-7.

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This implies that treatment of AgP in this population should include microbiological screening and aim at eradication of the bacterium when present. Development-specific responses to drought stress in Aleppo pine (Pinus halepensis Mill.) seedlings. As both Hox 3.1 and Pax3 serve to nifedipine 60 mg side effects regulate N-CAM expression, it is possible that abnormalities associated with N-CAM may compromise neural crest cell migration and normal neural tube closure. These features highlight the suitability of MCCs for the treatment of water polluted with metal and organic materials. Sedation reduces patient levels of anxiety and stress, facilitates the delivery of care and ensures safety.

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Influenza virus infection contributes to substantial morbidity and mortality globally. Retention of Campylobacter (Campylobacterales: Campylobacteraceae) in the house fly (Diptera: Muscidae). A prospective observational study comparing a non-operator dependent automatic PWV analyser to pulse pressure, in assessing arterial stiffness in hemodialysis. It is difficult to predict a high risk for developing bladder cancer in women with haematuria based solely on reproductive factors. Phase Behavior of Nonionic Microemulsions with Multi-end- adalat cr tablet capped Polymers and Its Relation to the Mesoscopic Structure.

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A type I interferon signature characterizes chronic antibody-mediated rejection in kidney transplantation. Correction: miRNA Repertoires of Demosponges Stylissa carteri and Xestospongia testudinaria. Health behaviours are important risk factors for DP irrespective of diagnosis groups. This is the first longitudinal investigation of the effects of exenatide in subjects with PWS. A third proband was doubly heterozygous for inherited rare variants in additional components of complex I, NDUFAF2 and NDUFB9, confirming that Histiocytoid CM is genetically heterogeneous. We searched the Pubmed, Cochrane Library, and the databases for relevant randomized, double-blind placebo-controlled trials up to August 2014 to perform a meta-analysis.

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The impact of lymph node density on OS and DSS remained significant on multivariate analysis, whereas conventional nodal staging was not. The etiology of myelodysplasia and its implication in liver transplantation is discussed. This outcome is supported by the methods of instrumental variables and latent variables, commonly used by econometricians for analyzing and evaluating social programs. Our results provide a promising framework to externally control the superconducting properties of iron-based materials. Animal amlodipine 10 mg norvasc models of cell cycle dysregulation and the pathogenesis of gliomas. Follow-up issues in children with mild traumatic brain injuries.

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