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Losartax (Losartan)
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Losartax

Losartax belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Losartax prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Losartax slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Angibloc, Angilock, Angizaar, Anreb, Arapres, Corodin, Enromic, Fensartan, Loortan, Lopress, Losacor, Losardil, Losartan, Losartas, Losartec, Losartic, Losartil, Losatrix, Losazid, Losium, Lostankal, Lostat, Lotan, Lotar, Lotim, Lozap, Lozar, Lyosan, Mozartan, Myotan, Osartan, Portiron, Prelow, Ranlozar, Rasertan, Resilo, Sarilen, Sarlo, Sarvas, Simperten, Sortiva, Temisartan, Tiasar, Tozaar, Xartan, Zaart

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Also known as: Losartan

Description

Losartax (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Losartax is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Losartax is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Losartax 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Losartax 25 mg, Losartax 50 mg, and Losartax 100 mg may also contain carnauba wax.

Dosage

Take Losartax tablets orally with or without food. Do not crush or chew it. Take Losartax once or twice a day at the same time. If you want to achieve most effective results do not stop taking Losartax suddenly.

Overdose

If you overdose Losartax and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Losartax overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Losartax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartax as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Losartax. Correct volume or salt depletion prior to administration of Losartax.

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Bevacizumab (Avastin) for retinopathy of prematurity: wrong dose, wrong drug, or both?. Our results suggest that the BI-1-mediated enhancement of lysosomal activity regulates P450 2E1 expression and resultant ROS accumulation. The effect of temperature on Leishmania (Kinetoplastida: Trypanosomatidae) development in sand flies. Mycophenolate mofetil is an effective and safe option for the management of systemic sclerosis-associated interstitial lung disease: results from the Australian Scleroderma Cohort Study. A cross-sectional study of the acquisition of grammatical morphemes in child speech. Eight open reading frames (ORFs) of at least 100 amino acids were identified. Visual evoked potential (VEP): basic concepts and clinical applications. Health affairs blog post: 1332 waivers and the future of state health reform.

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VCI in monochorionic twin pregnancies was not a risk factor for TTTS and severe perinatal morbidities. Therefore, understanding the immunopathogenesis of IBDV in both the spleen and the bursae could help effective vaccine development. Solubilization of porcine intestinal alpha-glucosidases and evidence for the separate identities of isomaltase and limit dextrinase. Among 225 participants (122 male, 103 female) with CLBP, patients with major depressive disorder and associated leg symptoms of CLBP had higher disability indices. The latter have not been previously identified in the lakes under study. Imaging of the ductus venosus in neonates: from patency to closure.

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Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension. According to a placebo-controlled double-blind within-subject design 25 healthy men attended three experimental sessions each. We divided the sample into 2 cohorts based on whether they had IBS, and formed subgroups based on age, sex, enrolment year, and enrolment month. Computerized analysis of breath sounds has relied on human auditory perception as the reference standard for identifying crackles. Nevertheless, there was no significant difference in T-cell activities among the three groups of mice that developed (a) no tumor, (b) skin papilloma, or (c) malignant skin tumor. Our data indicate that catalase-mediated oxidation of ethanol to acetaldehyde takes place mainly in aminergic neurons, which seem to have a limited capacity for the subsequent removal via aldehyde dehydrogenase. We have investigated the nucleolus of human type A spermatogonia, which displays a single, large fibrillar center. Tumoral calcinosis is an uncommon ectopic calcification syndrome characterized clinically by the presence of irregular, painless, periarticular soft tissue calcifying masses, and pathologically by fibrous-walled cystic spaces containing structureless calcific debris and associated with a variable inflammatory reaction. The extent of cross-reactivity was found to approximate the phylogenetic distances of the tested avian species.

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Six easy steps on how to create a lean sigma value stream map for a multidisciplinary clinical operation. The purposes of this study are to assess the efficacy of our intracranial surgery and evaluate the association between failure after first surgical repair and the risk factors that have been applied on a group of 13 patients affected by posttraumatic cerebrospinal fluid rhinorrhea associated with recurrent meningitis. The continuum in divergence time from Negritos to Senoi and Proto-Malay in combination with ancestral markers provides evidences of multiple waves of migration into SEA starting with the first Out-of-Africa dispersals followed by Early Train and subsequent Austronesian expansions. It is concluded that further long-term studies of indapamide are indicated in larger numbers of patients. Depression, anxiety and stress in patients hospitalised following injury is common and should be anticipated in patients who have had an intensive care admission. Fast classical molecular-dynamics simulations are combined with accurate density functional theory calculations predicting both quantum transport properties and molecular-dynamics force field parameters. No freshwater signal could be detected around the mangrove trees. we have previously conducted a community-based prevalence study of dementia in older adults living in the rural Hai district of Tanzania.

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Thiosteranes represented a high proportion of the steroid fraction in the Wroclaw irrigation field and the Nexapa River Basin samples. A simulation approach for the calculation of the LET-dependent yield of double-strand breaks (DSB) is presented. During the 10-year interval from 1990 to 2000 sixteen patients suffering from dog bite injuries were seen in our department. In spite of the removal of four ribs from one side and three ribs from the other, there were no postoperative respiratory problems. Our results demonstrate both the high level of structural p53 mimicry employed by PM2 to engage HDM2, and the potential resilience of stapled peptide antagonists to mutations in target proteins. Registered with International Standard Randomised Controlled Trial (identifier: ISRCTN93185560 ) on 10 November inderal 20 mg tablet uses in hindi 2014. Also, in vitro experiments showed that the NMDA-induced sensitization of cultured DRG neurons depends on satellite cell activation and on those same NMDAR subunits, suggesting their importance for the PGE2-induced hyperalgesia.

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The analyzed sRNAs show a different degree of conservation in Rhizobiales, and expression of homologs of BjrC2, BjrC68, BjrC1505, and 6S RNA was confirmed in the free-living purple bacterium Rhodopseudomonas palustris 5D. to contribute in a multimodal concept of anti-cancer therapy in future. Many severity scores have been proposed, but findings of validation studies have shown that they are not adequately calibrated. With known voice-coil displacement, voice-coil current, and stimulus signal as inputs, four calculation procedures for the direct problem, adjoint problem, sensitivity problem, and conjugate gradient method are involved in inversely solving the unknown electromechanical parameters. In this study, we applied this single-step method to analyze data for the maternal trait of total number of piglets born in Danish Landrace, Yorkshire, and two-way crossbred pigs in different scenarios. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Usefulness of conventional pleural drainage systems to predict the occurrence of prolonged air leak after anatomical pulmonary resection. Experiences of adolescents and young adults with ADHD in Hong Kong: treatment services and clinical management. Although palmitoylation is common in vaccinia virus envelope proteins, little is known about the role of palmitoylation in the biogenesis of the enveloped virus. 11C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorder.

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This demonstrated a significant reduction of the major membrane proteins. We designed this study to compare the hemodynamic repercussions of laryngoscopy and tracheal intubation (LTI) performed with either a Macintosh or the McCoy blade. Mucosal swab samples collected from 246 patients who were infected by HIV, did not have oral candidiasis, and were being treated with highly active antiretroviral therapy were analyzed. Detected clusters are well supported by comprehensible probabilistic parameters and retain a maximum amount of information, thus overcoming the present conflict of sensitivity and specificity in piRNA cluster detection. The goal of this article is to show that IMIA can also play the role of accreditation agency and to present the IMIA accreditation protocol and experiences obtained with it. This study examined feeding progression by assessing timing of acquisition of five early feeding milestones among EP infants and the impact of immaturity and medical complications.

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