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Losartax (Losartan)

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Losartax belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Losartax prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Losartax slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Angibloc, Angilock, Angizaar, Anreb, Arapres, Corodin, Enromic, Fensartan, Loortan, Lopress, Losacor, Losardil, Losartan, Losartas, Losartec, Losartic, Losartil, Losatrix, Losazid, Losium, Lostankal, Lostat, Lotan, Lotar, Lotim, Lozap, Lozar, Lyosan, Mozartan, Myotan, Osartan, Portiron, Prelow, Ranlozar, Rasertan, Resilo, Sarilen, Sarlo, Sarvas, Simperten, Sortiva, Temisartan, Tiasar, Tozaar, Xartan, Zaart

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Also known as: Losartan


Losartax (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Losartax is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Losartax is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Losartax 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Losartax 25 mg, Losartax 50 mg, and Losartax 100 mg may also contain carnauba wax.


Take Losartax tablets orally with or without food. Do not crush or chew it. Take Losartax once or twice a day at the same time. If you want to achieve most effective results do not stop taking Losartax suddenly.


If you overdose Losartax and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Losartax overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Losartax are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartax as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Losartax. Correct volume or salt depletion prior to administration of Losartax.

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After three weeks, the oxygen from the nitro groups was depleted and methane production commenced. Only M2 macrophages induced angiogenesis at levels comparable with highly angiogenic neutrophils previously shown to release their proMMP-9 in a unique form, free of tissue inhibitor of metalloproteinases-1 (TIMP-1). Furthermore, already preclinically, the temporal course of successive twitch amplitudes changed during repetitive stimulation at increasing rates. Lighting is crucial for detail rendition and 3D reproduction of the nose, and for apparent photographic bias. Transgenic fertile Scoparia dulcis L., a folk medicinal plant, conferred with a herbicide-resistant trait using an Ri binary vector.

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Knowledge of dementia community resources and stigma among Chinese American immigrants. Radar detection of motion through saltwater was also demonstrated at restricted ranges (1-2 cm) with low power transmission (10 dBm). In both processes, an energetically low lying vacancy is filled by an electron of an energetically higher lying orbital and a secondary electron is instantaneously emitted to the continuum. Effects of inhaled nitric oxide on hemostasis in healthy adults treated with heparin: a randomized, controlled, blinded crossover study. This study provides evidence for a role of the fractalkine-CX3CR1 signaling pathway in seizure-induced microglial activation and suggests that neuroblast production following seizures may partly occur as a result of microglial activation.

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Bevacizumab (Avastin) for retinopathy of prematurity: wrong dose, wrong drug, or both?. Our results suggest that the BI-1-mediated enhancement of lysosomal activity regulates P450 2E1 expression and resultant ROS accumulation. The effect of temperature on Leishmania (Kinetoplastida: Trypanosomatidae) development in sand flies. Mycophenolate mofetil is an effective and safe option for the management of systemic sclerosis-associated interstitial lung disease: results from the Australian Scleroderma Cohort Study. A cross-sectional study of the acquisition of grammatical morphemes in child speech. Eight open reading frames (ORFs) of at least 100 amino acids were identified. Visual evoked potential (VEP): basic concepts and clinical applications. Health affairs blog post: 1332 waivers and the future of state health reform.

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PepIV was selected from a phage display peptide library as a Nogo-66 binding molecule. Main pulmonary artery aneurysms with no underlying pathology are very rare, and the role of surgery in this entity is not well defined. Before and after either the intervention or wait-list period, older siblings completed measures of supervision knowledge and their supervision behaviors were unobtrusively observed when with their younger sibling. The results were compared with previously published findings obtained 12 and 18 months postoperative. The optical signal was collected by optical fiber, a grating was used for light diffraction, a digital micromirror device (DMD) was applied instead of traditional mechanical Hadamard masks for optical modulation, and an InGaAs near infrared detector was used as the optic sensor. In particular, we thoroughly present the nonlocal hydrodynamic model and the recently introduced generalized nonlocal optical response (GNOR) model. Previous work has shown that overexpression of FOG in Xenopus laevis causes loss of blood suggesting that in contrast to its role in mammals, FOG might normally function to repress erythropoiesis in this species.

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VCI in monochorionic twin pregnancies was not a risk factor for TTTS and severe perinatal morbidities. Therefore, understanding the immunopathogenesis of IBDV in both the spleen and the bursae could help effective vaccine development. Solubilization of porcine intestinal alpha-glucosidases and evidence for the separate identities of isomaltase and limit dextrinase. Among 225 participants (122 male, 103 female) with CLBP, patients with major depressive disorder and associated leg symptoms of CLBP had higher disability indices. The latter have not been previously identified in the lakes under study. Imaging of the ductus venosus in neonates: from patency to closure.

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To evaluate treatment strategies on MM cells, the effects of radiotherapy, docetaxel or a combination of both on MM cells derived from the sarcomatoid type ZL34 and the epithelial type M28K were investigated. Inside-out Regulation of Ectodomain Cleavage of Cluster-of-Differentiation-44 (CD44) and of Neuregulin-1 Requires Substrate Dimerization. Previous results have been hard to interpret because of methodological issues. Botulinum toxin type A (BoNT/A) is a metalloprotease that blocks synaptic transmission via the cleavage of a synaptosomal-associated protein of 25 kDa (SNAP-25). Urinary schistosomiasis caused by Schistosoma haematobium worms is endemic to tropical regions where it is the most common cause of hematuria. Based on sound preclinical evidence, several relatively small studies have examined radiotherapy (RT) with cetuximab in stage III NSCLC.

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Hypoxia-induced glucose-6-phosphate dehydrogenase overexpression and -activation in pulmonary artery smooth muscle cells: implication in pulmonary hypertension. According to a placebo-controlled double-blind within-subject design 25 healthy men attended three experimental sessions each. We divided the sample into 2 cohorts based on whether they had IBS, and formed subgroups based on age, sex, enrolment year, and enrolment month. Computerized analysis of breath sounds has relied on human auditory perception as the reference standard for identifying crackles. Nevertheless, there was no significant difference in T-cell activities among the three groups of mice that developed (a) no tumor, (b) skin papilloma, or (c) malignant skin tumor. Our data indicate that catalase-mediated oxidation of ethanol to acetaldehyde takes place mainly in aminergic neurons, which seem to have a limited capacity for the subsequent removal via aldehyde dehydrogenase. We have investigated the nucleolus of human type A spermatogonia, which displays a single, large fibrillar center. Tumoral calcinosis is an uncommon ectopic calcification syndrome characterized clinically by the presence of irregular, painless, periarticular soft tissue calcifying masses, and pathologically by fibrous-walled cystic spaces containing structureless calcific debris and associated with a variable inflammatory reaction. The extent of cross-reactivity was found to approximate the phylogenetic distances of the tested avian species.

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Six easy steps on how to create a lean sigma value stream map for a multidisciplinary clinical operation. The purposes of this study are to assess the efficacy of our intracranial surgery and evaluate the association between failure after first surgical repair and the risk factors that have been applied on a group of 13 patients affected by posttraumatic cerebrospinal fluid rhinorrhea associated with recurrent meningitis. The continuum in divergence time from Negritos to Senoi and Proto-Malay in combination with ancestral markers provides evidences of multiple waves of migration into SEA starting with the first Out-of-Africa dispersals followed by Early Train and subsequent Austronesian expansions. It is concluded that further long-term studies of indapamide are indicated in larger numbers of patients. Depression, anxiety and stress in patients hospitalised following injury is common and should be anticipated in patients who have had an intensive care admission. Fast classical molecular-dynamics simulations are combined with accurate density functional theory calculations predicting both quantum transport properties and molecular-dynamics force field parameters. No freshwater signal could be detected around the mangrove trees. we have previously conducted a community-based prevalence study of dementia in older adults living in the rural Hai district of Tanzania.

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Accumulation of uric acid in plasma after repeated bouts of exercise in the horse. SMCP is interfaced with the Eclipse TPS (Varian Medical Systems, Palo Alto, CA) which can thus be included into the inverse treatment planning process for MERT. Our working hypothesis that over-expression of this gene signature predicts poor survival outcome in GBM patients was confirmed, and in addition, it was demonstrated that the survival model was highly subtype-dependent, with strong dependence in the Proneural subtype and no detected dependence in the Classical and Mesenchymal subtypes. Rab3D localizes to secretory granules in rat pancreatic acinar cells. In this paper the authors report on the use of the endoscope in the CPA as a tool to increase the extent of resection, minimize complications, and preserve the function of the delicate CPA structures. Changes in fatty acid composition and distribution of N-3 moduretic medicine fatty acids in goat tissues fed different levels of whole linseed.

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These scores provide prognostic information for short-term clinical outcomes. The modified ilioinguinal and anterior intrapelvic approaches for acetabular fracture fixation: indications, quality of reduction, and early outcome. By combining biochemical approaches in human and yeast extracts with genetic analysis, much moduretic 25 mg has been learned about the RNA-RNA and RNA-protein interactions that are necessary to assemble the various complexes that are found along the pathway to the catalytically active spliceosome. Secondary outcomes were pain intensity and species of colonizing bacteria. These parasitic protists are usually transmitted by the faecal-oral route, following the ingestion of infective stages (oocysts or cysts). Effect of a beating process, as a means of reducing salt content in Chinese-style meatballs (kung-wan): a dynamic rheological and Raman spectroscopy study. Osteosarcoma (OS) is the most common pediatric primary malignant bone tumor.

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We obtained data on UKAs and TKAs from the Finnish Arthroplasty Registry and population data from Statistics Finland to analyze the incidence of UKAs and TKAs in Finland for the period 1980-2006. The aim of this study was to vasotec reviews examine the relationship among sedentary behaviour (SB) and the metabolic syndrome and its components by age, moderate-to-vigorous physical activity (MVPA) and sex. Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Doppler spectral analysis of the vertebral and internal mammary arteries should be integrated in ultrasound, especially in patients with cerebrovascular or cardiac symptoms. Recently, an updated Cochrane review was published, reaching the same general conclusion as the first one, i.e., GnRHa triggers lower the chance of pregnancy in fresh autologous IVF and intracytoplasmic injection treatment cycles. These results indicate that GERL is the primary site of endocytosis of presumed complexes of cholera toxin with its plasma membrane receptor (GM1 ganglioside-containing moieties). We propose solutions to decrease undesirable variations in the review of these studies.

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Mean blood arterial pressure, heart rate, pH, and lactates were tested during the liver grafting and at the end of the procedure in pigs that underwent autografting of the liver and compared with pigs that underwent an orthotopic liver allotransplantation. Prevalence of Upper Gastrointestinal Lesions at Primary Diagnosis in Adults with Inflammatory Bowel Disease. Administration of delayed-release tablets at a dosage of 5 mg/kg every other day can be considered for future studies. Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts. Specifically, the study sought to determine the combined and unique associations of legal status, the three immigration-related challenges listed above, and fear of deportation to acculturative stress related to family and other social bystolic medication patient reviews contexts. We examined cocaine-mediated change in regional cerebral blood volume (rCBV) and mean transit time (MTT) in central brain structures of rats using functional MR imaging techniques. This study suggests that a balanced step-down protocol, including both ICS and LABA, is essential in providing long-term stability to patients with mild-to-moderate well-controlled asthma. Flow cytometry revealed that the G/L ratio was significantly higher in the open group. Combined MEG-EEG source localisation in patients with sub-acute sclerosing pan-encephalitis.

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Thiosteranes represented a high proportion of the steroid fraction in the Wroclaw irrigation field and the Nexapa River Basin samples. A simulation approach for the calculation of the LET-dependent yield of double-strand breaks (DSB) is presented. During the 10-year interval from 1990 to 2000 sixteen patients suffering from dog bite injuries were seen in our department. In spite of the removal of four ribs from one side and three ribs from the other, there were no postoperative respiratory problems. Our results demonstrate both the high level of structural p53 mimicry employed by PM2 to engage HDM2, and the potential resilience of stapled peptide antagonists to mutations in target proteins. Registered with International Standard Randomised Controlled Trial (identifier: ISRCTN93185560 ) on 10 November inderal 20 mg tablet uses in hindi 2014. Also, in vitro experiments showed that the NMDA-induced sensitization of cultured DRG neurons depends on satellite cell activation and on those same NMDAR subunits, suggesting their importance for the PGE2-induced hyperalgesia.

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The analyzed sRNAs show a different degree of conservation in Rhizobiales, and expression of homologs of BjrC2, BjrC68, BjrC1505, and 6S RNA was confirmed in the free-living purple bacterium Rhodopseudomonas palustris 5D. to contribute in a multimodal concept of anti-cancer therapy in future. Many severity scores have been proposed, but findings of validation studies have shown that they are not adequately calibrated. With known voice-coil displacement, voice-coil current, and stimulus signal as inputs, four calculation procedures for the direct problem, adjoint problem, sensitivity problem, and conjugate gradient method are involved in inversely solving the unknown electromechanical parameters. In this study, we applied this single-step method to analyze data for the maternal trait of total number of piglets born in Danish Landrace, Yorkshire, and two-way crossbred pigs in different scenarios. However, little is known about how the HOPS complex is recruited to lysosomes in mammalian cells. Usefulness of conventional pleural drainage systems to predict the occurrence of prolonged air leak after anatomical pulmonary resection. Experiences of adolescents and young adults with ADHD in Hong Kong: treatment services and clinical management. Although palmitoylation is common in vaccinia virus envelope proteins, little is known about the role of palmitoylation in the biogenesis of the enveloped virus. 11C-PiB imaging of human immunodeficiency virus-associated neurocognitive disorder.

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Tumor delineation, visualization of hepatic parenchyma, and feeding vessels are clearly possible using imaging protocol 2 with ultrafast CBCT imaging. Enzyme-catalyzed reporter deposition (CARD) resulted in immunofluorescence signal amplification. To examine whether a familial tendency exists in clinical response to methylphenidate. Based on the structures of the metabolites, we have developed an extraction procedure to determine the concentration of the parent compound in plasma. Electrophysiological evidence is presented that at least 30 percent of sartorius muscle fibres of adult frogs are innervated by two or more axons at a single end-plate zone. Our findings propose Stat3/Snail pathway as a novel therapeutic target for the treatment of progression and metastasis of HCC with CSC-like signatures and epithelial-mesenchymal transition phenotype. He could walk without a cane and there was no evidence of recurrence at 1.5 years after surgery. After model adjustment, current asthma status was significantly associated with past month and year serious psychological distress among veterans only. We critically review important fundamental concepts and innovative applications in addition to detailed analysis by multiphysics approaches. The outcome of rectal cancer after early salvage TME following TEM compared with primary TME: a case-matched study.

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The prevention, diagnosis and management of central venous line infections in children. The identification of in vitro hemolysis (IVH) using a hematology analyzer is challenging because centrifugation of the specimens cannot be performed for cell counts. Oxygen for relief of dyspnoea in people with chronic obstructive pulmonary disease who would not qualify for home oxygen: a systematic review and meta-analysis. Understanding the connection between platelet-activating moduretic brand name factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer. Of these candidates, pancreatic polypeptide (PPY) and IgM showed a significant association with NAB. Cytotoxicity generated under these conditions has the same genetic requirements for I-region histoincompatibility between stimulator and responder, and for K or D identity of stimulator and target cell, as has been reported for peripheral cell CTL. We find that illnesses or deaths among livestock, dogs and fish are all potentially useful as sentinel events for the presence of harmful cyanobacteria that may impact human health.

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This demonstrated a significant reduction of the major membrane proteins. We designed this study to compare the hemodynamic repercussions of laryngoscopy and tracheal intubation (LTI) performed with either a Macintosh or the McCoy blade. Mucosal swab samples collected from 246 patients who were infected by HIV, did not have oral candidiasis, and were being treated with highly active antiretroviral therapy were analyzed. Detected clusters are well supported by comprehensible probabilistic parameters and retain a maximum amount of information, thus overcoming the present conflict of sensitivity and specificity in piRNA cluster detection. The goal of this article is to show that IMIA can also play the role of accreditation agency and to present the IMIA accreditation protocol and experiences obtained with it. This study examined feeding progression by assessing timing of acquisition of five early feeding milestones among EP infants and the impact of immaturity and medical complications.

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