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Losartan belongs to a class of drugs called angiotensin receptor blockers (ARBs). It works by relaxing blood vessels so that blood can flow more easily. It is taken by mouth. It may be used alone or in addition to other blood pressure medication.

Other names for this medication:
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Losartan is indicated for the treatment of hypertension in adults and pediatric patients 6 years of age and older, to lower blood pressure. Lowering blood pressure lowers the risk of fatal and nonfatal cardiovascular (CV) events, primarily strokes and myocardial infarction. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes including losartan.

Control of high blood pressure should be part of comprehensive cardiovascular risk management, including, as appropriate, lipid control, diabetes management, antithrombotic therapy, smoking cessation, exercise, and limited sodium intake. Many patients will require more than 1 drug to achieve blood pressure goals. For specific advice on goals and management

Losartan is indicated to reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients

Losartan is indicated for the treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria in patients with type 2 diabetes and a history of hypertension. In this population, Losartan reduces the rate of progression of nephropathy as measured by the occurrence of doubling of serum creatinine or end stage renal disease


Take Losartan tablets orally with or without food. Do not crush or chew it. Take Losartan once or twice a day at the same time. If you want to achieve most effective results do not stop taking Losartan suddenly.


If you overdose Losartan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Losartan overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Losartan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Losartan as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Losartan. Correct volume or salt depletion prior to administration of Losartan.

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This study identifies the most popular online resources for patient information about abdominoplasty and evaluates their readability in the context of average American literacy. This level of expression was found to continue for the duration of cell culture maintenance and a fully functional protein was produced. Role of activated macrophage and inflammatory cytokines in the development of calcinosis in juvenile dermatomyositis. Physical function was assessed using the Berg Balance Scale (BBS), the Timed Up and Go Test (TUGT), and the lower extremity of Fugl-Meyer Assessment. After double digested by NcoI and XbaI, the derp2 fragment is ligated to the same double-digested pNZ8148 vector. When frontal sinus preservation is in doubt, controversy surrounds the use of cranialization versus obliteration, and the method of obliteration. The measures developed here elucidate some elements that influence attitudes and purchase intentions for CT and may inform policy efforts to curtail the development of illicit markets. Malnutrition is frequent among older people and is associated with morbi-mortality. Cell-wall properties contributing to improved deconstruction by alkaline pre-treatment and enzymatic hydrolysis in diverse maize (Zea mays L.) lines.

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Effect of dehusking and cooking on protein and dietary fibre of different genotypes of desi, kabuli and green type chickpeas (Cicer arietinum). Thus, specific neural signatures across these regions hold representations of different emotional states in multimodal fashion, independently of how the emotions are induced. Hereditary angioedema (HAE) is a rare and potentially life-threatening condition that results from mutations in the C1 inhibitor (C1-INH). In addition, our patient was able to induce motor responses upon request. This study investigated differences in EEG coherence measures between two groups of children with Attention-Deficit/Hyperactivity Disorder (AD/HD) - one with the more common EEG profile (increased theta), and a group with excess alpha activity as the dominant EEG abnormality. Naltrexone efficacy for smoking cessation varies across AA individuals with different levels of WA ancestry. Psychiatric patients have an elevated risk of suicide while in hospital. The University of Pennsylvania Smell Identification Test (UPSIT) was administered to 81 participants at baseline (identification of risk for psychosis) and 254 individuals at follow-up.

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Nineteen plant extracts obtained from plants from the Brazilian Amazon showed activity against planktonic Streptococcus mutans, an important bacterium involved in the first steps of biofilm formation and the subsequent initiation of several oral diseases. A significant correlation was found between the dose and the plasma level of warfarin. The aim of the study was to investigate the characteristics and outcome of Acute Kidney Injury (AKI) developing in patients with cirrhosis treated with NSAIDs. Migration of polyolefin oligomeric saturated hydrocarbons (POSH) into food. Estimation of pairwise sequence similarity of mammalian enhancers with word neighbourhood counts. The surface conductivities of hydrogenated cBN films increased by 3-6 orders after the deposition of surface dopants. The study of the structure factor of a wormlike chain in an orientational external field. Dnmt1 is required for HSPC maintenance via cebpa regulation during definitive hematopoiesis in zebrafish.

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Associations between neighborhood effects and physical activity, obesity, and diabetes: The Jamaica Health and Lifestyle Survey 2008. However intake data collected for a short period are a limited estimator of long-term usual intake. The preliminary descriptive analyses of the incidence of infections among TEDDY participants younger than 4 years fits well with general knowledge of infectious disease epidemiology. The diagnosis can be established when typical findings in EBUS guided fine needle aspirates or surgical biopsies are found in combination with a positive serology. Livestock models have contributed significantly to biomedical and surgical advances. Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. The models include a constant time lag, and it is shown that this lag has a critical value above which oscillations in blood cell concentration occur.

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However, the ability of miRNAs to modulate dendritic cells (DCs) function for allergen immunotherapy is unclear. Given emerging evidence that early interventions may improve functioning and reduce symptomatology while also lowering risk of transition to full-threshold psychosis, several randomized controlled trials have systematically evaluated the efficacy of CHR treatment approaches. Here, Twitcher mice were simultaneously treated with CNS-directed gene therapy, substrate reduction therapy, and bone marrow transplantation to target the primary pathogenic mechanism (GALC deficiency) and two secondary consequences of GALC deficiency (psychosine accumulation and neuroinflammation). The purpose of this study was to review the clinical characteristics of the antrochoanal polyp (ACP) and to compare the differences between children and adults. The size of the difference was sufficiently large to raise not only normative but quality and safety concerns.

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Although serous carcinomas are rare, these highly aggressive tumors account for a disproportionate number of endometrial cancer deaths. This study successfully elucidated the pharmacokinetic profiles of EWH extract and five EWH-derived prenylflavonoid monomers in rats. Specific areas of noncomparability identified include intervention characteristics and country context, as well as differences in methodological considerations, including data sources and definition of cost centers. Emergent cesarean section in the catheterization laboratory for spontaneous coronary artery dissection. Cytotoxic efficacy was determined to be very good for 2 of the systems, both of which achieved complete cell death on at least 1 cell line at physiologically attainable prodrug concentrations. Besides, the surface-active oil-soluble initiator can penetrate into the interfacial layer.

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Study participants were (1) 220 older adults participating in a 15-week combined exercise and education falls prevention programme and (2) 9 practitioners (3 home-care nurses, 5 community workers, and an exercise physiologist) involved in delivering the programme. In initial studies, both eIF4E and 4E-BP1 were expressed as recombinant proteins coupled to variants of green fluorescent protein (ECFP and EYFP, respectively). A combination of triclosan with amphotericin B or with fluconazole enhanced their fungicidal effects. After an overall mean follow-up time of 25.3 months, six patients were still alive at the time of this analysis with no evidence of disease. The objective of this study is to contribute to the positioning of the intravenous digital subtraction angiography (IVDSA) in the detection of morphologic abnormalities of renal arteries (RAs), susceptible to originate renovascular hypertension (RVH).

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The basic fibroblast growth factor (bFGF) gene locus is transcribed into a number of mRNA transcripts including an antisense mRNA derived from the opposite DNA strand of the bFGF gene. This class of RNAs is thought to be functionally important because many individual miRNAs are evolutionally conserved across widely diverse phyla. Haemarthrosis and arthropathy do not favour the development of factor VIII inhibitors in severe haemophilia A mice. Among them, surgical approaches including curettage and partial sternotomy were performed in only 6 cases. The focus here is on the Hyp O-glycosylation of cell wall proteins. A prominent demonstration of this developmental plasticity is their ability to bend organs in order to reach the position most optimal for growth and utilization of light, nutrients, and other resources. Micromitra burgessensis individuals are preserved on hard skeletal elements, including conspecific shells, Tubulella and frequently on the spicules of the sponge Pirania muricata, providing direct evidence of an ecological association between two species. However, patient selection for CRT in congenital heart disease is still challenging because the clinical standard for CRT in these patients is not established. We report a series of cases of a newly described entity, genetic thrombocytopenia with mutation in the ankyrine 26 gene, diagnosed from the exploration of five pediatric cases of thrombocytopenia.

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Clinical utility for imaging and interventional diagnostics of hepatic lesions. Huntington disease (HD) is an autosomal dominant neurodegenerative disorder, characterized by motor, psychiatric and cognitive symptoms. No significant effect of elevated CO2 was detected on the relative abundance of major groups of microalgae and benthic diatom species. The amotosalen/UVA-treated PCs confirmed previously published results with a slight increase of PSLs compared to untreated PCs. Fetomaternal transfusion as a cause of severe fetal anemia causing early neonatal death: a case report. Evidence of gallbladder function changes in hepatoma after transcatheter arterial embolization by quantitative Tc-99m DISIDA cholescintigraphy. Several hundred plants were routinely regenerated using this protocol. However, even with this a distinction between alternative models ultimately depends upon analysis of a variety of kinetic experiments.

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Finally, we present some key unanswered questions and remaining challenges to be addressed by the field. This study sought to measure epigenetic markers across pregnancy and early postpartum and identify markers that could be used as predictors for conversion from GDM to type 2 diabetes. This measure is grounded upon the concept of Granger causality and can be estimated by modeling neural spike trains as point process generalized linear models. The experimental results show that an o-hydroxy group on the cinnamenyl motif of chalcone derivatives plays a crucial role at the reaction sites for the regioselective Michael addition. Coronary aneurysm formation following biodegradable polymer drug-eluting stent implantation. Dysfunctional uterine bleeding in adolescent girls and evaluation of their response to treatment. In the absence of inhalation anesthetics in the BLM system, no ion transport current flowed between W1 and W2 across the BLM. A 34 year old woman was admitted with a generalized tonic-clonic seizure, fever and confusion following her 40th infusion of natalizumab.

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The operating technique is described in such a way as to limit complications to a minimum. Diagnostic categories of nonsarcoid inflammatory, neoplastic, and neurosarcoid were based on their final myelopathic diagnosis. This study aims to evaluate emotional factors such as anxiety and depression, and the Quality of Life of individuals with chronic persistent pain after amputation in order to identify the interindividual variation in response to pain. Epidemiologic approach to control of sexually transmitted disease. Interaction of proteins with other molecules plays an important role in many biological activities. The full term group was initially examined at the age of 3 days until a full response was observed. After quantifying how much was learned in object exploration and identifying the time course of practice-related gains in exploration efficiency (speed), we identified what was learned. MECC with SDS as micellar phase allows to separate the amino acid derivatives and to resolve the diastereomers. One sediment core was obtained from the center of Yamenqi Lake at the Songnen Plain in eastern China in August 2010 using a gravity corer. This case provides key learning points, particularly highlighting the value of prompt, accurate clinical assessment and the importance of adhering to the clinical diagnostic formulation.

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Here, we provide an overview of our current understanding of the role and regulation of zinc in promoting proliferation, differentiation and secretion in the mammary gland during lactation what is the use of inderal 10 mg , and highlight critical gaps in knowledge. Bullying among adolescents has become the subject of extensive research due to its negative effects on attitude and behavior. To evaluate the impact of a simulation on pharmacy student attitudes toward poverty using the Attitude toward Poverty (ATP) Short Form scale. It can be concluded from this study that iron fortification of household drinking water is a simple and effective alternative for developing countries along with other technological approaches to iron fortification of foods. The map has been interpreted with the aid of a computer program which systematically searched for the best fit between the electron-density map and the known coordinates of individual immunoglobulin domains. Campylobacter jejuni clone SA recently emerged as the predominant cause of sheep abortion in the United States and is also associated with foodborne gastroenteritis in humans. Prohibitin exerts beneficial effects on neurons by reducing mitochondrial free radical production.

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Nevertheless, increased knowledge of AP may achieve more thorough understanding of the pathogenesis. Assessment of technique for rapid detection of Escherichia coli and Proteus species in urine by head-space gas-liquid chromatography. Lack of effect of an acute ileal perfusion of short-chain fatty acids on glucose metabolism in healthy men. Somatic hybridization between potato and Nicotiana plumbaginifolia : 2. Worldwide, systemic infections with BL enzymes are evolving by mutations from classical bla genes in an intensified manner and they continue to be transferred across species. Practical procedures, developed using in vitro tissue culture, can be a simple and reliable preservation option of potato genetic resources rather than maintaining by vegetative propagation in adalat la 30 mg uses in urdu genebanks due their allogamous nature.

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This study asks whether early bilingual speakers who have already developed a language control mechanism to handle two languages control a dominant and a late acquired language in the same way as late bilingual speakers. Genomic potential for nitrogen assimilation in uncultivated members of Prochlorococcus from an anoxic marine zone. A descriptive design with a qualitative approach was used to follow health care personnel before, during and after implementation of a care prevention intervention. Our vasotec dose pathogenic pattern, may be summarised in 7 propositions : - psoriasis is a proliferative disease of the epidermis. To determine NaCl effects on callus growth and antioxidant activity, callus of a salt-tolerant and a salt-sensitive cultivar of cotton was grown on media amended with 0, 75, and 150 mM NaCl.

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Tissue-tissue synchrony is especially important in the musculoskeletal system, wherein overall organ function is enabled by the seamless integration of bone with soft tissues such as ligament, tendon, or cartilage, as well as the integration of muscle with tendon. Review of the literature provides a clearer understanding of the presentations and management. Conventional epoxy resin embedding techniques require the use of propylene oxide as a clearing agent. Immunohistochemical evaluation of nm23-H1 gene product in transitional cell carcinoma of the bladder. Unipept ( is a web application that offers a user-friendly way to explore the biodiversity of complex metaproteome samples by providing interactive visualizations. A conceptual cognitive architecture for robots to learn behaviors from demonstrations in robotic aid area. The development of gallstones must be accepted as an anticipated risk whenever estrogens or clofibrate are prescribed. The human gammaherpesviruses take advantage of normal B cell differentiation pathways to establish life-long infection in memory B cells.

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Assessment of anodal and cathodal transcranial direct current stimulation (tDCS) on MMN-indexed auditory sensory processing. Third, we decompose the total scatter matrix by using singular value decomposition and construct a new data matrix by using singular values and left singular vectors. A total of 41 wild boar specimens, including 19, 10, 10, and 2 specimens from the Lesser-Caucasus, the Greater Caucasus, the Kura-Araks lowland, and Lankaran natural region were studied. However, we cannot be overlooked or neglected the complication of laparoscopic inguinal hernia repair although it brings us lots of benefits. At the latter time point, pubertal development was additionally correlated with enhanced responses to faces in temporal pole, ventrolateral prefrontal cortex (PFC) and dorsomedial PFC. Many WHO member states (120/194) did not have any data on NTD prevalence.

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Biomimetic calcium phosphate coating was formed on titanium surface and BSA was incorporated into the coating through co-deposition. The specific aims were to: 1) identify the self-reported eHealth literacy levels, and 2) determine differences in levels of eHealth literacy between pre-nursing and nursing students. An autopsy demonstrated extensive meningeal and parenchymal brain involvement by small cell carcinoma. Mechanical effects of ET-1 in cardiomyocytes isolated from normal and heart-failed rabbits. Five children with Sharp syndrome are described presenting a non-erosive polyarthritis, hand and finger swelling, Raynaud phenomenon, myositis, dermatomyositis or SLE-like rash. Outbreak of ovine congenital toxoplasmosis in Iran, confirmed by different diagnostic methods. Correct nomination of at least one symptom, risk factor, prevention or treatment of diabetes was made by 6.1 per cent of participants. The partial thrombosis of the right corpus cavernosum was hypothesized. On this view, skilled action is the imposition of constraints on the co-variation of movement and sensory flux such that the boundary conditions that define the skill are met. The serum IgE concentration is significantly lower in aged as compared with young people.

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Jaundice in hyperemesis gravidarum may cause physicians to suspect several underlying diseases. Moreover, the growing number of industrial microalgal species genetically modified will allow the production of novel strains with enhanced carotenoid contents. Since entering our cells in an endosymbiotic event one billion years ago cordarone 200 mg costo , mitochondria have shaped roles for themselves in metabolism, inflammation, calcium storage, migration, and cell death. External salicylate slows the falling phase of the action potential, with little effect on the action potential amplitude. Co-application of lidocaine and QX-572 induces divergent pain behaviours in mice.

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Time-course experiments revealed that vascular changes preceded node transformation. This is a simple way to prepare biodegradable films compared with other methods and the blend films have the potentiality to be used as food packaging and biomedical materials instead of synthetic polymer. As the activity of neuronal pathways may vary in activity at different chronological ages, the present study was undertaken to further evaluate the role of serotonergic pathways in the regulation of serum PRL levels. It is shown that a modern sunscreen can provide a spectrally balanced absorption profile in line with shade and many types of clothing fabric. Large number of hapten-specific and H-2-restricted CTL could be generated by repeated exposure to fresh supernatant. The various methods of treatment include open myomectomy, laparoscopic or robot-assisted myomectomy, medical treatment, uterine artery embolization and magnetic resonance guided focused ultrasound surgery. Experimental results demonstrate that the proposed method can accurately detect source activities correlated to the given multiple reference signals, even when unknown latencies exist between the source and references. Comments on Cecconi et al.: consensus on circulatory shock and hemodynamic monitoring. Square wave jerks and anxiety as distinctive biomarkers for anorexia nervosa. Pharmacokinetics and tolerance of ketoprofen administered rectally.

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The outcome of lopressor xl dosage treatment with LDL-apheresis in young patients, using the most recently introduced techniques, is reported. Tools that allow rapid and cost-effective access to functional data of lncRNAs are therefore essential. The Translocation Domain of Botulinum Neurotoxin A Moderates the Propensity of the Catalytic Domain to Interact with Membranes at Acidic pH. B-cell depletion using rituximab (RTX) has proven efficacy in patients with RA. Target organs of infection in guinea pigs with acquired congenital syphilis. The findings from this analysis may be useful for maternity health professionals and policy makers when responding to the needs of women choosing to use hypnotherapy for intrapartum pain management. Methane activation by metal-free Lewis acid centers only--a computational design and mechanism study. In contrast, two of the leukemic T-cell lines and four normal control B-cell lines were not radiosensitive.

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Further investigation should explore test-retest reliability, sensitivity to change, concordance between caregiver and child-completed forms, and the calibration of the utility weights. To evaluate shoulder functional results and the retear rate of arthroscopic repair of the rotator cuff augmented with platelet-rich coreg 25 mg bid to metoprolol plasma (PRP). This article presents 3 additional cases of BFH of the oral mucosa, with a review of previously published cases. These results underscore the need to augment disease-centric management approaches with holistic strategies to reduce the population burden of HF. Splenomegaly in murine trypanosomiasis: T cell-dependent phenomenon. By taking the advantage of synchronous pulsatility, the TORVAD delivers full hemodynamic support with nearly half the VAD flow rate (2.7 L/min compared with 5.3 L/min for the HMII) by allowing the left ventricle to eject during systole and thus preserving native aortic valve flow (3.0 L/min compared with 0.4 L/min for the HMII, down from 3.1 L/min at baseline).

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