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Losacar (Losartan)

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Losacar slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes. to treat patients with high blood pressure (hypertension) in adults and in children and adolescents 6 - 18 years of age.

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Also known as: Losartan


Losacar (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Losacar is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Losacar is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Losacar 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Losacar 25 mg, Losacar 50 mg, and Losacar 100 mg may also contain carnauba wax.


Take Losacar tablets orally with or without food. Do not crush or chew it. Take Losacar once or twice a day at the same time. If you want to achieve most effective results do not stop taking Losacar suddenly.


If you overdose Losacar and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Losacar overdosage: fainting, feeling lightheaded, rapid heartbeat.


Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

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The most common side effects associated with Losacar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.


Do not take Losacar if you are allergic to Losacar components. Do not take Losacar if you're pregnant or you plan to have a baby, or you are a nursing mother. Losacar can harm your baby. Do not use Losacar if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Losacar if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Losacar suddenly.

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In this study we evaluate and compare the profiles and the dynamics of variation of CG expression in peripheral blood, and two lymphoid tissues of mice. microRNA profiling: increased expression of miR-147a and miR-518e in progressive supranuclear palsy (PSP). To study the clinicopathologic features of Hodgkin lymphoma (HL) occurring in northern China, association with Epstein-Barr virus (EBV) infection and concordance between EBV protein immunohistochemistry (IHC) and in-situ hybridization (ISH). Whether infant growth patterns add to the prediction of later overweight should be further studied. No correlations were demonstrated between peroperative graft flow on one hand and the presence or absence of ventricular dyskinesia or electrocardiographic evidence of previous transmural myocardial infarction on the other. Exclusively suprasellar xanthogranulomas are exceptional and this report presents a very rare case in the pediatric population, particularly unique due to the presence of calcification. It was found that the linked Si/C nanospheres with a diameter of 400-500 nm contain Si, Cu(x)Si, and Cu nanocrystals, which are highly dispersed in the amorphous carbon nanospheres. Many studies have reported that the resting heart rate (HR) is intimately related to the prognosis of cardiovascular disease.

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Populations, not clones, are the unit of vibrio pathogenesis in naturally infected oysters. Accumulating evidence suggests a role for oxidative stress in the pathophysiology of schizophrenia. Microvessel density was increased in tumour tissues that expressed COX-2 and VEGF-A, suggesting that COX-2 and VEGF-A are related to tumour angiogenesis in human renal cell carcinoma. Presence of mild hypothyroidism in type 2 diabetes confers a protective effect with respect to glucose tolerance and redox balance whereas presence of overt hypothyroidism in type 2 diabetes has a deleterious effect. Evolution, development, and plasticity of the human brain: from molecules to bones. Simultaneous metering and dispensing of multiple reagents on a passively controlled microdevice solely by finger pressing. Multiple Plasmids Contribute to Antibiotic Resistance and Macrophage Survival In Vitro in CMY2-Bearing Salmonella enterica. All these approaches have helped to define specific targets or systems to improve the management of food safety. Clinical handover practice of faculty-level critical care physicians did not conform to any of the three predefined structuring schemes.

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Discovery of a 29-gene panel in peripheral blood mononuclear cells for the detection of colorectal cancer and adenomas using high throughput real-time PCR. IBC revealed as a substance which can produce a very efficient and lasting embolization. The aim of the present study was to investigate the effects and safety of a patent ductus arteriosus occluder (PDAO) in the management of major abdominal arteriovenous fistula. To elucidate the role of caspase-8 in lung carcinoma, we used human samples of non-small cell lung cancer (NSCLC) and a mouse model of carcinogen-induced lung cancer. Comparison of three screening tests for autism in preterm children with birth weights less than 1,500 grams. A case of severe duodenal hemorrhage in a septic renal allograft recipient is presented in which successful occlusion of the gastroduodenal artery by Gelfoam emboli also resulted in severe hepatic infarction and gallbladder necrosis. About 35 mg/kg PTZ were is diovan a beta blocker medication used for EEG recording after ceftriaxone administiration. Short-term myocardial hibernation of 3 hours resulting from a moderate resting coronary flow reduction has been reproduced in pigs.

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Results obtained from restriction mapping, deletion subclonings, and mini-Mu-LacZ fusions indicated that the repB gene was contained within a 0.8-kb HindIII-PstI region. Our findings show that FEM correlations thought to prevent perceptual fading exist even in highly dynamic real-world conditions. Fcgamma-receptors are type I transmembrane molecules that carry extracellular parts consisting of two or three immunoglobulin domains. However, therapeutic impact is restrained due to shortage of pancreas organ donors and instant inflammation occurring in the hepatic environment of the graft. One hundred and twenty-four subjects were selected, the preoperative cone-beam CT (CBCT) data was analyzed by NNT software, which provided a three-dimensional measurement of the maxillary sinus septa. These smaller designs finally satisfy the prediction of the retention of MPHB, PPHB and PE also.

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