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Lortaan (Losartan)
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Lortaan

Lortaan is used to treat patients with chronic heart failure when therapy with specific medicines called angiotensin-converting-enzyme inhibitors (ACE inhibitors, medicine used to lower high blood pressure) is not considered suitable by your doctor. If your heart failure has been stabilised with an ACE inhibitor you should not be switched to Lortaan.

Other names for this medication:
Angizaar, Asart, Cardoplus, Cormac, Corus, Hilos, Hypozar, Insaar, Lepitrin, Loben, Loortan, Lopernal, Lopress, Losagen, Losalet, Losamet, Losart, Losartax, Losatrix, Losavik, Losazide, Losium, Lozap, Ozarium, Portiron, Prelow, Rasoltan, Rosatan, Sarlo, Sarvas, Sarvastan, Stadazar, Tarnasol

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Altace, Trandate, Minipress, Diovan, Inderal, Benicar

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Also known as: Losartan

Description

Lortaan (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Lortaan is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Lortaan is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Lortaan 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Lortaan 25 mg, Lortaan 50 mg, and Lortaan 100 mg may also contain carnauba wax.

Dosage

Take Lortaan tablets orally with or without food. Do not crush or chew it. Take Lortaan once or twice a day at the same time. If you want to achieve most effective results do not stop taking Lortaan suddenly.

Overdose

If you overdose Lortaan and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Lortaan overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Lortaan are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Lortaan if you are allergic to Lortaan components. Do not take Lortaan if you're pregnant or you plan to have a baby, or you are a nursing mother. Lortaan can harm your baby. Do not use Lortaan if you are taking salt substitutes or potassium supplements, other blood pressure medicine, diuretic (water pill). It can be dangerous to use Lortaan if you suffer from or have a history of liver disease, kidney disease, heart failure. If you want to achieve most effective results without any side effects it is better to avoid alcohol. Avoid machine driving. Do not stop taking Lortaan suddenly.

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Although we found no reason to adapt the underlying framework, recommendations were made for further development to enable use in different tumor- and treatment modalities and in larger (international) samples that allow for more advanced statistical analysis. The introduction of high resolution/accurate mass instruments with fast sequencing capabilities has enabled the development of novel quantitative methods. Device-related damaging events included medication administration events, infections, hematomas, retained catheter fragments, cerebrospinal fluid leaks, cord or cauda equina trauma, device placed at wrong level, stimulator incorrectly programmed, delay in recognition of granuloma formation, and other issues. Recently the Sauve-Kapandji (S-K) procedure has become popular for the treatment of various distal radioulnar joint (DRUJ) disorders. Left ventricular systolic dysfunction in asymptomatic Marfan syndrome patients is related to the severity of gene mutation: insights from the novel three dimensional speckle tracking echocardiography. A vascularized mass, which had developed at the expense of the vagus nerve, was removed surgically. The release of metal ions was increased by galvanic corrosion due to contact between base metal and titanium, and it can cause adverse effects on the tissue around the implant by inducing cytotoxicity. In particular, cyclin E-cdk2 levels remain high during both S-phase and mitosis. A spiroketal-enol ether derivative from Tanacetum vulgare selectively inhibits HSV-1 and HSV-2 glycoprotein accumulation in Vero cells.

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We have generated Pan-HER, a mixture of six antibodies targeting each of the HER family members EGFR, HER2, and HER3 with synergistic pairs of antibodies, which simultaneously remove all three targets, thereby preventing compensatory tumor promoting mechanisms within the HER family. Increased CHD risk does not appear to be a reason for lowering the upper thyrotropin reference limit. All had severe metabolic acidosis and visual impairment and three pancreatitis. The current study confirms that variants of CISH are associated with susceptibility to TB, suggesting that negative regulators of cytokine signaling may have a role in immunity against TB infection. In this Letter we present for the first time a systematic study of the effect of stacking faults on the optical properties of self-assembled photonic crystals, by means of large-scale transmittance calculations for macroscopic slabs of inverted opals with randomly distributed stacking faults. The eight-correlated first-order factors showed the best fit to the data in comparison to the unidimensional solution and hierarchical models. Flexible endoscopes produce high-quality images, are small in size, and can deliver microsurgical instruments or laser probes. The individual functions of MAPK pathway components in tumor initiation and progression vary depending on the stimuli and the stromal cell types involved in tumor progression, in addition to the molecular isoforms of the components and the origins of the tumor.

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