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Lopernal (Losartan)
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Lopernal

Lopernal belongs to a family of medications known as angiotensin II receptor blockers. These medications are used in adults and children over the age of six to lower mild-to-moderate hypertension (high blood pressure).

Other names for this medication:
Aratan, Cardzaar, Corodin, Corus, Fortzaar, Gitox, Insaar, Lacine, Loctenk, Lohyp, Lopress, Lorista, Losadrac, Losap, Losar, Losarb, Losargamma, Losatrix, Losavik, Losazide, Losium, Lostan, Lostat, Lotim, Lozatan, Lozitan, Lyosan, Ocsaar, Omnitan, Rasoltan, Stadazar, Temisartan, Tensartan, Xartan, Zartan

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Moduretic, Trandate, Bystolic, Lozol, Lopressor

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Also known as: Losartan

Description

Lopernal (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Lopernal is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Lopernal is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Lopernal 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Lopernal 25 mg, Lopernal 50 mg, and Lopernal 100 mg may also contain carnauba wax.

Dosage

Take Lopernal tablets orally with or without food. Do not crush or chew it. Take Lopernal once or twice a day at the same time. If you want to achieve most effective results do not stop taking Lopernal suddenly.

Overdose

If you overdose Lopernal and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Lopernal overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Lopernal are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Changes in renal function including acute renal failure can be caused by drugs that inhibit the reninangiotensin system and by diuretics. Patients whose renal function may depend in part on the activity of the renin-angiotensin system (e.g., patients with renal artery stenosis, chronic kidney disease, severe congestive heart failure, or volume depletion) may be at particular risk of developing acute renal failure on COZAAR. Monitor renal function periodically in these patients. Consider withholding or discontinuing therapy in patients who develop a clinically significant decrease in renal function on Lopernal.

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