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Loben (Losartan)
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Loben

Loben belongs to a group of drugs called angiotensin II receptor antagonists (sometimes called ARB blockers). It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Loben is used to treat high blood pressure (hypertension) in adults and children who are at least 6 years old. It is also used to lower the risk of stroke in certain people with heart disease.

Other names for this medication:
Angibloc, Arapres, Corodin, Corus, Cozzar, Enromic, Fensartan, Fortzaar, Loctenk, Loortan, Loplac, Lorista, Lortaan, Losacar, Losadrac, Losagen, Losakind, Losan, Losartax, Losartil, Lostad, Lotar, Loxibin, Lyosan, Mozartan, Myotan, Omnitan, Osartil, Prosan, Ranlozar, Rosatan, Satoren, Sedeten, Sortiva, Tacardia, Tarnasol, Tensartan, Xartan, Zartan

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Also known as: Losartan

Description

Loben (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Loben is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Loben is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Loben 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Loben 25 mg, Loben 50 mg, and Loben 100 mg may also contain carnauba wax.

Dosage

Take Loben tablets orally with or without food. Do not crush or chew it. Take Loben once or twice a day at the same time. If you want to achieve most effective results do not stop taking Loben suddenly.

Overdose

If you overdose Loben and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Loben overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Loben are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Loben as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Loben. Correct volume or salt depletion prior to administration of Loben.

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