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Insaar (Losartan)
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Insaar

Insaar belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Insaar prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Insaar slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
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Also known as: Losartan

Description

Insaar (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Insaar is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Insaar is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Insaar 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Insaar 25 mg, Insaar 50 mg, and Insaar 100 mg may also contain carnauba wax.

Dosage

Take Insaar tablets orally with or without food. Do not crush or chew it. Take Insaar once or twice a day at the same time. If you want to achieve most effective results do not stop taking Insaar suddenly.

Overdose

If you overdose Insaar and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Insaar overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Insaar are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Insaar as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Insaar. Correct volume or salt depletion prior to administration of Insaar.

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Ketamine hydrochloride, commonly used as a pediatric anesthetic agent, is an N-methyl-D-aspartic (NMDA) acid receptor antagonist with rapid onset and short duration of action. Ovine pulmonary adenocarcinoma (OPA) is a naturally occurring lung cancer of sheep caused by jaagsiekte sheep retrovirus (JSRV). Grape seed extract and Zinc containing nutritional food supplement delays onset and progression of Streptozocin-induced diabetic cataract in Wistar rats. However, patients with an AIRD have a compromised immune system, which is further impaired by medication. Recently, protection in shock (hemorrhagic or septic) by physostigmine has been demonstrated. Introducing this biomarker into research and the clinical arena can significantly increase the power of clinical trials targeting abnormal accumulations of TDP-43 or Tau, and select the appropriate patients for target-specific therapies. Sentinel lymph node detection using magnetic resonance lymphography with conventional gadolinium contrast agent in breast cancer: a preliminary clinical study. Ingestion of beef alone caused a sharp rise in these parameters. Beware of mental health commissions bearing gifts to primary care.

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We show the functionality of Knowledge EXplorer on an example of water quality evaluation. Three blocks of rest data (one after each of the specified prior states) were acquired on each of 25 subjects. After a review of the main radiosurgical published series, to evaluate our own series of 705 patients with cerebral arteriovenous malformations treated by radiosurgery alone or in combination with embolization or surgery. A randomized control trial of a chronic care intervention for homeless women with alcohol use problems. The phages displaying peptides identified by this study have potential applications for cargo delivery and receptor studies. A pharmacokinetic-pharmacodynamic analysis revealed that the potency for QTc prolongation of IMI was 1.7-fold higher than that of FLV. Risk and protective factors were included only if a minimum of two methodologically sound research studies reviewed the variable. It is very helpful in improving the daily clinical setup accuracy. Quality of life is related to injury severity, age and sleep symptoms. We present six patients with primary aneuploidies and a suspected or confirmed secondary genetic diagnosis or unusual birth defect.

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