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Diclotride (Amiloride)
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Diclotride

Diclotride is a new, orally administered, potassium-sparing diuretic with mild natriuretic and diuretic properties. Its primary site of action is the distal tubule of the nephron where it selectively blocks sodium transport, thereby inhibiting sodium-potassium exchange.

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Also known as: Amiloride

Description

Diclotride is a diuretic (water pill) and a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The amiloride component helps minimize potassium loss. Brand name of Diclotride is Diclotride.

Dosage

Take Diclotride by mouth with food. Diclotride may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm. If you want to achieve most effective results do not stop taking Diclotride suddenly.

Overdose

If you overdose Diclotride and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Do not freeze. Keep container closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Diclotride are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Diclotride if you are allergic to Diclotride components or to any ingredient in Diclotride or any other sulfonamide (eg, sulfamethoxazole). Be careful with Diclotride if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Diclotride if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Be careful with Diclotride if you have allergies to medicines, foods, or other substances. Be careful with Diclotride if you have cirrhosis or liver problems, diabetes, gout, kidney problems or kidney stones, asthma, heart problems, or systemic lupus erythematosus. Be careful with Diclotride if you have elevated blood acid, low folic acid levels, or electrolyte problems, or are dehydrated. Be careful with Diclotride if you take potassium-sparing diuretics (eg, spironolactone), potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart; cholestyramine or colestipol because they may decrease Diclotride 's effectiveness; nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Diclotride 's effectiveness and risk of kidney problems may be increased; barbiturates (eg, phenobarbital), certain chemotherapy medicines, corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, narcotic pain medicines (eg, codeine), or medicines for high blood pressure because the risk of their side effects may be increased by Diclotride; diazoxide, lithium, or nondepolarizing neuromuscular blockers (eg, pancuronium) because their actions and the risk of their side effects may be increased by Diclotride; angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) because the risk of high blood potassium and kidney problems may be increased by Diclotride; diabetes medicines (eg, glipizide) or insulin because their effectiveness may be decreased by Diclotride. Do not stop taking Diclotride suddenly.

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Chemical accessibility of 18S rRNA in native ribosomal complexes: interaction sites of mRNA, tRNA and translation factors. In order to study the histological structure of healthy and pathological furcations in the rat, two groups of animals were submitted to two different diets: one normal and one rich in sucrose. Therapeutic potential of nitric oxide synthase gene manipulation. Thus the kinetic sugar uptake phenomena by the TBY-2 cells were well confirmed overall using the developed method. The aim of this study was to investigate ventilation in children undergoing FB by measuring carbon-dioxide (CO2 ) levels using the transcutaneous technique. Data on 566 consecutive patients with colorectal liver metastasis (CLM) between 1989 and 2010 were analyzed. Molecular typing and immunoblotting of 17 Mycoplasma ovipneumoniae isolates from China. Distant metastasis reportedly often occurs long after initial primary RCC treatment.

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Parent programs for latino families with young children: social, cultural, and linguistic considerations. Dermatitis by Tropical Rat Mite, Ornithonyssus bacoti (Mesostigmata, Macronyssidae) in Italian city-dwellers: a diagnostic challenge. The mechanistic basis of prostacyclin and its stable analogues in pulmonary arterial hypertension: Role of membrane versus nuclear receptors. Not all the prostate-specific instruments used to assess outcomes after surgical treatment for localized prostate cancer have been validated for use in this population. The present study aimed to investigate actual rates of mental stress (posttraumatic stress disorder, syndromal depression and syndromal anxiety) in Rwanda and to examine if gender, persecution during the genocide, readiness to reconcile as well as importance given to religiosity and quality of religiosity are predictors of mental stress. We present a framework for identifying disease states by classifying cells in the pathological regions of tissues into different categories. IV liposomal quercetin in combination with RF ablation reduces tumor growth rates and improves animal endpoint survival.

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Radiation-induced fibrosis: mechanisms and implications for therapy. Incidence of anaerobic bacterial infection following transurethral instrumentation. Negative control included the omitting of primary antibody and replacing it by buffer solution. To investigate whether laughter therapy lowers total mood disturbance scores and improves self-esteem scores in patients with cancer. However, few reports have focused on lateral wedging of cemented vertebra after kyphoplasty. Workshops of the Fifth International Brain-Computer Interface Meeting: Defining the Future.

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To summarize the efficacy of DAAs and to describe optimal treatment regimens for chronic hepatitis C. Calcium signals in helper T cells after interaction with antigen-specific and antigen-nonspecific B cells. Experimental groups were divided into four groups of six rats of both WAG/Rij and Wistar strains with 2 and 6 months of age. Comparison of efficacy of different embolic agents on uterine leiomyoma. Hyperhomocysteinemia which is caused by abnormal homocysteine metabolism has been confirmed to be related to cardio-cerebrovascular disease, peripheral vascular disorders, neurodegenerative diseases, diabetes, pregnancy-induced hypertension syndrome, liver cirrhosis, chronic kidney disease. Our results indicate that hybrid and multifunctional PHBV/SPION/CEF nanoparticles are suitable as a superparamagnetic drug delivery system that can guide, concentrate and site-specifically release drugs with antibacterial activity. Years after the first report on 1,4-dihydropyridines (1,4-DHPs) and 1,2,3,4-tetrahydropyrimidines (1,2,3,4-THPMs) appeared, they are revisited as plausible therapeutic agents. Oral administration of 50 mg/kg/day grape-seed extract was started 15 days before bile duct ligation and continued to the adalat 60 mg second operation in the study group. Different views of the causes of health disparities are discussed, particularly in light of cultural competency training and other efforts to ameliorate health disparities.

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