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Araten (Losartan)
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Araten

Araten belongs to a group of medicines known as angiotensin-II receptor antagonists. Angiotensin-II is a substance produced in the body which binds to receptors in blood vessels, causing them to tighten. This results in an increase in blood pressure. Araten prevents the binding of angiotensin-II to these receptors, causing the blood vessels to relax which in turn lowers the blood pressure. Araten slows the decrease of kidney function in patients with high blood pressure and type 2 diabetes.

Other names for this medication:
Anreb, Aratan, Covance, Eklips, Faxiven, Giovax, Loctenk, Lohyp, Loortan, Loplac, Losacar, Losadrac, Losagen, Losamet, Losap, Losapot, Losaprex, Losart, Losartan, Losavik, Losazid, Losazide, Losium, Lotim, Lozap, Mozartan, Omnitan, Osartil, Ozarium, Prosan, Rasoltan, Sanipresin, Sarilen, Sarlo, Sartens, Satoren, Sortiva

Similar Products:
Trandate, Lozol, Lanoxin, Norvasc, Aceon, Moduretic, Microzide

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Also known as: Losartan

Description

Araten (losartan potassium) is an angiotensin II receptor blocker acting on the AT1 receptor subtype. Losartan potassium, a non-peptide molecule, is chemically described as 2-butyl-4-chloro-1-[p-(o-1Htetrazol- 5-ylphenyl)benzyl]imidazole-5-methanol monopotassium salt.

Araten is a white to off-white free-flowing crystalline powder with a molecular weight of 461.01. It is freely soluble in water, soluble in alcohols, and slightly soluble in common organic solvents, such as acetonitrile and methyl ethyl ketone. Oxidation of the 5-hydroxymethyl group on the imidazole ring results in the active metabolite of losartan.

Araten is available as tablets for oral administration containing either 25 mg, 50 mg or 100 mg of losartan potassium and the following inactive ingredients: microcrystalline cellulose, lactose hydrous, pregelatinized starch, magnesium stearate, hydroxypropyl cellulose, hypromellose, and titanium dioxide.

Araten 25 mg, 50 mg and 100 mg tablets contain potassium in the following amounts: 2.12 mg (0.054 mEq), 4.24 mg (0.108 mEq) and 8.48 mg (0.216 mEq), respectively. Araten 25 mg, Araten 50 mg, and Araten 100 mg may also contain carnauba wax.

Dosage

Take Araten tablets orally with or without food. Do not crush or chew it. Take Araten once or twice a day at the same time. If you want to achieve most effective results do not stop taking Araten suddenly.

Overdose

If you overdose Araten and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Araten overdosage: fainting, feeling lightheaded, rapid heartbeat.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Keep container tightly closed. Throw away any unused medicine after the expiration date. Keep out of the reach of children in a container that small children cannot open.

Side effects

The most common side effects associated with Araten are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Use of drugs that act on the renin-angiotensin system during the second and third trimesters of pregnancy reduces fetal renal function and increases fetal and neonatal morbidity and death. Resulting oligohydramnios can be associated with fetal lung hypoplasia and skeletal deformations. Potential neonatal adverse effects include skull hypoplasia, anuria, hypotension, renal failure, and death. When pregnancy is detected, discontinue Araten as soon as possible.

In patients with an activated renin-angiotensin system, such as volume- or salt-depleted patients (e.g., those being treated with high doses of diuretics), symptomatic hypotension may occur after initiation of treatment with Araten. Correct volume or salt depletion prior to administration of Araten.

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Metastatic choriocarcinoma transplanted with cadaver kidney: a case report. While the role of prolactin in promoting the development of the crop-sac in members of the pigeon family (Columbiformes) is well established, its action in the central nervous system is less well understood. The second case was 66-year-old woman having a unstable blood pressure and having periodic chest pain and back pain after admission. Premature loss of primary teeth: part I, its overall effect on occlusion and space in the permanent dentition. It may also be necessary to take into account possible modulating effects of the MHC on other recognized human genes. Age is the most important determinant for the presence of multiple tumors and is a crucial factor for the aggressiveness of the disease. The versatile structural and chemical properties combined with the high resolution cell imaging capabilities of this system are an important step towards the better understanding and control of cell interactions with nanomaterials. The present study was undertaken to investigate the hepcidin expression in psoriasis patients.

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