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Acesistem (Amiloride)
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Acesistem

Acesistem is a new, orally administered, potassium-sparing diuretic with mild natriuretic and diuretic properties. Its primary site of action is the distal tubule of the nephron where it selectively blocks sodium transport, thereby inhibiting sodium-potassium exchange.

Other names for this medication:
Amiloride, Bpzide, Bumeftyl, Cibadrex, Cilazil, Cosaar, Crinoretic, Duopril, Enaplus, Eprotan, Hidroronol, Hydrene, Inhibace, Iperton, Lisoretic, Lodoz, Lorzaar, Monopril, Prestole, Renacor, Rofucal, Selokomb, Timolide, Triampur, Triamteril

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Also known as: Amiloride

Description

Acesistem is a diuretic (water pill) and a combination of a potassium-sparing diuretic (amiloride) and a thiazide diuretic (hydrochlorothiazide). It works by making the kidneys eliminate sodium (salt) and water from the body, which helps to lower blood pressure. The amiloride component helps minimize potassium loss. Brand name of Acesistem is Acesistem.

Dosage

Take Acesistem by mouth with food. Acesistem may increase the amount of urine or cause you to urinate more often when you first start taking it. To keep this from disturbing your sleep, try to take your dose before 6 pm. If you want to achieve most effective results do not stop taking Acesistem suddenly.

Overdose

If you overdose Acesistem and you don't feel good you should visit your doctor or health care provider immediately.

Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Do not freeze. Keep container closed tightly. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Side effects

The most common side effects associated with Acesistem are:

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Side effect occurrence does not only depend on medication you are taking, but also on your overall health and other factors.

Contraindications

Do not take Acesistem if you are allergic to Acesistem components or to any ingredient in Acesistem or any other sulfonamide (eg, sulfamethoxazole). Be careful with Acesistem if you're pregnant or you plan to have a baby, or you are a nursing mother. Be careful with Acesistem if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement. Be careful with Acesistem if you have allergies to medicines, foods, or other substances. Be careful with Acesistem if you have cirrhosis or liver problems, diabetes, gout, kidney problems or kidney stones, asthma, heart problems, or systemic lupus erythematosus. Be careful with Acesistem if you have elevated blood acid, low folic acid levels, or electrolyte problems, or are dehydrated. Be careful with Acesistem if you take potassium-sparing diuretics (eg, spironolactone), potassium supplements, or salt substitutes containing potassium because high blood potassium levels may occur and cause listlessness, confusion, abnormal skin sensations of the arms and legs, heaviness of limbs, slowed heart rate, irregular heart rhythm, or stopping of the heart; cholestyramine or colestipol because they may decrease Acesistem 's effectiveness; nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, indomethacin) because they may decrease Acesistem 's effectiveness and risk of kidney problems may be increased; barbiturates (eg, phenobarbital), certain chemotherapy medicines, corticosteroids (eg, prednisone), digoxin, dofetilide, ketanserin, narcotic pain medicines (eg, codeine), or medicines for high blood pressure because the risk of their side effects may be increased by Acesistem; diazoxide, lithium, or nondepolarizing neuromuscular blockers (eg, pancuronium) because their actions and the risk of their side effects may be increased by Acesistem; angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) because the risk of high blood potassium and kidney problems may be increased by Acesistem; diabetes medicines (eg, glipizide) or insulin because their effectiveness may be decreased by Acesistem. Do not stop taking Acesistem suddenly.

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